肾血管系统中肾素细胞的可塑性。
Plasticity of Renin Cells in the Kidney Vasculature.
作者信息
Gomez R Ariel, Lopez Maria Luisa S Sequeira
机构信息
University of Virginia School of Medicine, Child Health Research Center, 409 Lane Road, MR4 Building Room 2001, Charlottesville, VA, 22908, USA.
出版信息
Curr Hypertens Rep. 2017 Feb;19(2):14. doi: 10.1007/s11906-017-0711-8.
Abstract
During development, renin cells are precursors for arteriolar smooth muscle, mesangial cells, and interstitial pericytes. Those seemingly differentiated descendants retain the memory to re-express renin when there is a threat to homeostasis. Understanding how such molecular memory is constructed and regulated would be crucial to comprehend cell identity which is, in turn, intimately linked to homeostasis.
摘要
在发育过程中，肾素细胞是小动脉平滑肌、系膜细胞和间质周细胞的前体。那些看似已分化的后代细胞保留了在体内稳态受到威胁时重新表达肾素的记忆。了解这种分子记忆是如何构建和调控的，对于理解细胞身份至关重要，而细胞身份又与体内稳态密切相关。
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