Calle-Miguel L, Pérez-Méndez C, Miguel-Martínez M D, Lombraña-Álvarez E, García-García E, Solís-Sánchez G
Laura Calle-Miguel, Servicio de Pediatría, Hospital de Cabueñes 6ª planta Impar, C/ Los Prados, 395, CP 33394 Gijón, Asturias, Spain.
Rev Esp Quimioter. 2017 Apr;30(2):90-95. Epub 2017 Feb 22.
Streptococcus pyogenes is a significant cause of bacterial infections in children. The aim of the study is to analyse resistance rates and phenotypes of S. pyogenes isolates in a paediatric population in Northern Spain over the last 11 years.
Descriptive retrospective study of S. pyogenes isolates from paediatric patients between 2005 and 2015 in a region of Asturias (Spain). Resistance rates and changes in erythromycin resistance phenotypes in two time periods (2005-2009 and 2010-2015) were studied.
A total of 1,794 S. pyogenes isolates were registered (70% from 2005 to 2009). 87.5% were obtained from pharyngeal swabs and 0.2% from blood cultures. Resistance rates to tetracycline (8.8% to 4.3%, p=0.02), erythromycin (22% to 9.3%, p<0.01) and clindamycin (6% to 1.7%, p<0.01) decreased between the two study periods. A reduction in erythromycin-resistant isolates with the MLSB phenotype was observed.
A decrease in S. pyogenes resistance rates to erythromycin and clindamycin and a change in the erythromycin resistance phenotype were observed along the study period.
化脓性链球菌是儿童细菌感染的重要病因。本研究旨在分析过去11年西班牙北部儿科人群中化脓性链球菌分离株的耐药率和表型。
对西班牙阿斯图里亚斯地区2005年至2015年儿科患者的化脓性链球菌分离株进行描述性回顾性研究。研究了两个时间段（2005 - 2009年和2010 - 2015年）的耐药率及红霉素耐药表型的变化。
共记录了1794株化脓性链球菌分离株（2005年至2009年占70%）。87.5%来自咽拭子，0.2%来自血培养。两个研究时间段之间，对四环素的耐药率（从8.8%降至4.3%，p = 0.02）、红霉素（从22%降至9.3%，p < 0.01）和克林霉素（从6%降至1.7%，p < 0.01）均有所下降。观察到具有MLSB表型的红霉素耐药分离株减少。
在研究期间，观察到化脓性链球菌对红霉素和克林霉素的耐药率下降，以及红霉素耐药表型的变化。
