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本文引用的文献

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The sensitivity of staphylococci and other wound bacteria to erythromycin, oleandomycin, and spiramycin.葡萄球菌及其他伤口细菌对红霉素、竹桃霉素和螺旋霉素的敏感性。
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Streptococcus pyogenes erythromycin resistance in Italy.意大利化脓性链球菌对红霉素的耐药性
Emerg Infect Dis. 1999 Mar-Apr;5(2):302-3. doi: 10.3201/eid0502.990223.
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Resistance of Streptococcus pyogenes to erythromycin and related antibiotics in Italy. The Italian Surveillance Group for Antimicrobial Resistance.意大利化脓性链球菌对红霉素及相关抗生素的耐药性。意大利抗菌药物耐药性监测小组。
Clin Infect Dis. 1998 Aug;27 Suppl 1:S87-92. doi: 10.1086/514908.
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Erythromycin resistance of Streptococcus pyogenes in Madrid.马德里化脓性链球菌的红霉素耐药性
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Emergence of erythromycin-resistant, clindamycin-susceptible Streptococcus pyogenes isolates in Madrid, Spain.西班牙马德里出现对红霉素耐药、对克林霉素敏感的化脓性链球菌分离株。
Antimicrob Agents Chemother. 1998 Apr;42(4):989-90. doi: 10.1128/AAC.42.4.989.
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Antibiotic susceptibility of group A streptococci in 2 Italian cities: Milano and Catania.意大利两个城市米兰和卡塔尼亚的A组链球菌的抗生素敏感性
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The role of macrolides in Streptococcus pyogenes pharyngitis.大环内酯类药物在化脓性链球菌性咽炎中的作用。
J Antimicrob Chemother. 1997 May;39(5):562-5. doi: 10.1093/jac/39.5.562.
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Rapid increase of resistance to erythromycin and clindamycin in Streptococcus pyogenes in Italy, 1993-1995. The Italian Surveillance Group for Antimicrobial Resistance.1993 - 1995年意大利化脓性链球菌对红霉素和克林霉素耐药性的快速增长。意大利抗菌药物耐药性监测小组。
Emerg Infect Dis. 1996 Oct-Dec;2(4):339-42. doi: 10.3201/eid0204.960410.
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Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system.对大环内酯类耐药但对克林霉素敏感的肺炎链球菌和化脓性链球菌：一种由外排系统介导的常见耐药模式。
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意大利化脓性链球菌中的红霉素耐药性。

Erythromycin resistance in Streptococcus pyogenes in Italy.

作者信息

Bassetti M, Manno G, Collidà A, Ferrando A, Gatti G, Ugolotti E, Cruciani M, Bassetti D

机构信息

Infectious Diseases Department, University of Genoa, G. Gaslini Children's Hospital, Genoa, Italy.

出版信息

Emerg Infect Dis. 2000 Mar-Apr;6(2):180-3. doi: 10.3201/eid0602.000212.

DOI:10.3201/eid0602.000212
PMID:10756153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2640849/
Abstract

In a prospective study of acute pharyngitis in Italian children, 69 (38.3%) of 180 isolates of Streptococcus pyogenes were resistant to macrolides. S. pyogenes was eradicated in 12 (63.1%) of 19 patients with erythromycin-resistant S. pyogenes treated with clarithromycin and in 22 (88%) of 25 patients with erythromycin-susceptible strains. The constitutive-resistant phenotype was correlated with failure of macrolide treatment.

摘要

在一项针对意大利儿童急性咽炎的前瞻性研究中，180株化脓性链球菌分离株中有69株（38.3%）对大环内酯类耐药。在19例感染对红霉素耐药的化脓性链球菌的患者中，12例（63.1%）使用克拉霉素治疗后化脓性链球菌被清除；在25例感染对红霉素敏感菌株的患者中，22例（88%）被清除。组成型耐药表型与大环内酯类治疗失败相关。