Bassetti M, Manno G, Collidà A, Ferrando A, Gatti G, Ugolotti E, Cruciani M, Bassetti D
Infectious Diseases Department, University of Genoa, G. Gaslini Children's Hospital, Genoa, Italy.
Emerg Infect Dis. 2000 Mar-Apr;6(2):180-3. doi: 10.3201/eid0602.000212.
In a prospective study of acute pharyngitis in Italian children, 69 (38.3%) of 180 isolates of Streptococcus pyogenes were resistant to macrolides. S. pyogenes was eradicated in 12 (63.1%) of 19 patients with erythromycin-resistant S. pyogenes treated with clarithromycin and in 22 (88%) of 25 patients with erythromycin-susceptible strains. The constitutive-resistant phenotype was correlated with failure of macrolide treatment.
在一项针对意大利儿童急性咽炎的前瞻性研究中，180株化脓性链球菌分离株中有69株（38.3%）对大环内酯类耐药。在19例感染对红霉素耐药的化脓性链球菌的患者中，12例（63.1%）使用克拉霉素治疗后化脓性链球菌被清除；在25例感染对红霉素敏感菌株的患者中，22例（88%）被清除。组成型耐药表型与大环内酯类治疗失败相关。
