Mileva Zh, Maleeva A
Vutr Boles. 1987;26(4):70-4.
The basic ACTH and cortisol (hydrocortisone) secretion was followed up in 678 patients suffering from bronchial asthma--494 men and 184 women, duration of the disease from 6 months up to 27 years. In 140 patients the 24 hour secretion of both hormones was studied. In 1/3 of the asthmatic patients the cortisol secretion was lower than the normal one (20.94%) or was near the lower normal range (14.01%). In about half of the patients the morning (at 8 o'clock) ACTH secretion was increased (53.10%). The disturbance of the basic hypophysial-suprarenal secretion was found more often in the patients with infectious bronchial asthma (24.9%) and with the mixed form than with the atopic form of the disease (12.0%). It probably takes part in the pathogenesis of infectious bronchial asthma. The corticosteroid treatment plays a leading role in reducing the basic cortisol secretion in asthmatic patients. In 53.85% of the asthmatic patients a disturbed 24 hour rhythm of cortisol secretion was found--inverse (30.71%) or monotone (27.14%). The rhythm disturbance was found more often in the patients with basic hypocortisolemia.
对678例支气管哮喘患者（494例男性和184例女性，病程6个月至27年）的促肾上腺皮质激素（ACTH）和皮质醇（氢化可的松）基础分泌情况进行了随访。对140例患者的两种激素24小时分泌情况进行了研究。三分之一的哮喘患者皮质醇分泌低于正常水平（20.94%）或接近正常下限范围（14.01%）。约一半患者早晨8点促肾上腺皮质激素分泌增加（53.10%）。基础垂体 - 肾上腺分泌紊乱在感染性支气管哮喘患者（24.9%）和混合型患者中比在特应性哮喘患者（12.0%）中更常见。它可能参与感染性支气管哮喘的发病机制。皮质类固醇治疗在降低哮喘患者基础皮质醇分泌方面起主导作用。53.85%的哮喘患者存在皮质醇分泌24小时节律紊乱——反向（30.71%）或单调（27.14%）。节律紊乱在基础皮质醇血症患者中更常见。
