Mileva Zh, Maleeva A, Khristov G
Vutr Boles. 1990;29(4):84-7.
The basic level and the 24 h rhythm of secretion of cortisol, aldosterone, androstanedion, DHEA-sulfate and testosterone were determined in 26 men with bronchial asthma, 19 up to 50 years of age, in a free from attacks period. 20 of the patients had never been treated with corticosteroids and 6 patients had used corticosteroid drugs. In 26.32% of the patients who had not been treated with corticosteroids the basic cortisole level was either decreased or on the lower normal limit. At the same time in 55% of these patients a different degree increase of the basic DHEA-sulfate level was found and in 30% of the patients the androstanedione basic level was increased. The changes in the 24 h rhythm of androstanedione and DHEA-sulfate secretion were similar to those of cortisol. Normal rhythm of secretion of cortisol, aldosterone and testosterone was established mainly in patients with preserved basic hormonal secretion. In contrast to these, normal rhythm of androstanedione and DHEA-sulfate secretion was found more frequently in patients with increased basic secretion of these hormones.
在26名年龄在50岁及以下、处于哮喘缓解期的支气管哮喘男性患者中，测定了皮质醇、醛固酮、雄烷二酮、硫酸脱氢表雄酮和睾酮的基础水平及24小时分泌节律。其中20例患者从未接受过皮质类固醇治疗，6例患者曾使用过皮质类固醇药物。在未接受皮质类固醇治疗的患者中，26.32%的患者皮质醇基础水平降低或处于正常下限。与此同时，在这些患者中，55%的患者硫酸脱氢表雄酮基础水平有不同程度升高，30%的患者雄烷二酮基础水平升高。雄烷二酮和硫酸脱氢表雄酮24小时分泌节律的变化与皮质醇相似。皮质醇、醛固酮和睾酮的正常分泌节律主要在基础激素分泌正常的患者中建立。与此相反，在这些激素基础分泌增加的患者中，更常发现雄烷二酮和硫酸脱氢表雄酮的正常分泌节律。
