[Effect of activation and blocking of the GABA-ergic system during disorders of memory trace reproduction].

Analysis of the effects of activation and blocade of GABA-ergic system showed significant changes in the level of reproduction of conditioned reaction of passive avoidance in mice--lowering under administration of muscimol and baclopfen and increase under administration of picrotoxin and bicucullin in a dose of 1 mg/kg. Sharp lowering was observed of the efficiency of activating influence of drugs depressing the activity of GABA-ergic system at a long interval from the moment of administration of "psychogenic" amnestic agent. Dependence was established of the drugs influence on the type of memory disturbance: higher value of bicucullin and picrotoxin in retrieval of memory trace disturbed by cycloheximide in comparison to "psychogenic" amnesia. On the basis of the obtained results a suggestion is made on the significance of GABA-ergic mechanisms in regulation of reproduction processes.