Influence of changes in the effectiveness of blockade of the benzodiazepine-GABA ionophore complex on the reproduction of the amnestic memory trace in mice after preliminary administration of diazepam.

A comparative analysis was carried out in experiments on mice, using the methodology of the conditioned passive avoidance reaction, of the effectiveness of the blockade of the BD-GABA ionophore complex and its individual components in the recovery of a memory trace following "psychogenic" amnesia developing against the background of preliminary activation of BD-receptors by diazepam. It was shown that an improvement in the reproduction of the conditioned reaction was observed on the second day under conditions of "neurochemical tuning" only with the blockade of the GABAA receptor by bicuculline. Flumazepil and picrotoxin did not elicit an improvement in the reproduction of the reaction. A similar relationship of the effectiveness of the pharmacological actions was observed on the 21st day after training and "psychogenic" amnesia. The facts presented permit the hypothesis that the development of "psychogenic" amnesia is determined by the functional state, which governs the possibility of retrieving the memory trace, of the mediator systems of the brain during learning and the amnestic influence.