Eroshkin Fedor M, Zaraisky Andrey G
Laboratory of Molecular Bases of Embryogenesis, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Genesis. 2017 Apr;55(4). doi: 10.1002/dvg.23026. Epub 2017 Mar 17.
Cell movements during embryogenesis produce mechanical tensions that shape the embryo and can also regulate gene expression, thereby affecting cell differentiation. Increasing evidence indicates that mechanosensitive regulation of gene expression plays important roles during embryogenesis by coupling the processes of morphogenesis and differentiation. However, the molecular mechanisms of this phenomenon remain poorly understood. This review focuses on the molecular mechanisms that "translate" mechanical stimuli into gene expression.
胚胎发育过程中的细胞运动产生机械张力，这种张力塑造了胚胎，还能调节基因表达，从而影响细胞分化。越来越多的证据表明，基因表达的机械敏感性调节在胚胎发育过程中通过将形态发生和分化过程联系起来发挥着重要作用。然而，这一现象的分子机制仍知之甚少。本综述聚焦于将机械刺激“转化”为基因表达的分子机制。
