Brockhoff Hans C, Kim Roderick Y, Braun Thomas M, Skouteris Christos, Helman Joseph I, Ward Brent B
Oral and Maxillofacial Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan.
Head Neck. 2017 May;39(5):974-979. doi: 10.1002/hed.24724. Epub 2017 Feb 25.
The purpose of this study was to investigate the critical primary tumor depth of invasion in oral squamous cell carcinoma that would lead to a 20% or greater risk of nodal metastasis.
An institutional review board approved retrospective review of our head and neck database was performed from 2009 to 2014 and the data were statistically analyzed.
Two hundred eighty-six patients with a diagnosis of oral squamous cell carcinoma who met our inclusion criteria underwent primary excision and neck dissection. For a depth of invasion of 1 mm or less, there were no patients with a positive node. From 1.1 mm to 2 mm of depth of invasion, there was 1 of 11 patients (9%) who had at least 1 positive node. At 2.1 mm to 3 mm, 5 of 25 patients (20%) had at least 1 positive node.
Depth of invasion and the location of the tumor are 2 important variables to consider when making treatment recommendations to patients with clinical N0 disease. © 2017 Wiley Periodicals, Inc. Head Neck 39: 974-979, 2017.
本研究旨在调查口腔鳞状细胞癌中导致区域淋巴结转移风险达到20%或更高的关键原发肿瘤浸润深度。
对2009年至2014年经机构审查委员会批准的我们头颈数据库进行回顾性研究，并对数据进行统计分析。
286例符合纳入标准的口腔鳞状细胞癌患者接受了原发灶切除和颈部清扫术。浸润深度为1毫米或更小时，无患者出现淋巴结阳性。浸润深度在1.1毫米至2毫米时，11例患者中有1例（9%）至少有1个阳性淋巴结。在2.1毫米至3毫米时，25例患者中有5例（20%）至少有1个阳性淋巴结。
浸润深度和肿瘤位置是向临床N0期疾病患者提出治疗建议时需要考虑地两个重要变量。©2017威利期刊公司。《头颈》2017年第39卷：974 - 979页。
