Pandit Prakash, Patil Roshankumar, Palwe Vijay, Gandhe Sucheta, Manek Dhruti, Patil Rahul, Roy Sirshendu, Yasam Venkata Ramesh, Nagarkar Viren Raj, Nagarkar Raj
Department of Radiation Oncology, HCG Manavata Cancer Centre, Nashik, Maharashtra 422011 India.
Department of Pathology, HCG Manavata Cancer Centre, Nashik, Maharashtra 422011 India.
Indian J Otolaryngol Head Neck Surg. 2023 Sep;75(3):1511-1516. doi: 10.1007/s12070-023-03637-0. Epub 2023 Mar 4.
The present study examines the role of demographic and pathological features of primary tumours in predicting neck metastasis in early oral cavity cancers, which has been a matter of debate.
A single-centre, retrospective, institution review was conducted of all the patients presented to our centre from January 2014 to December 2021. Patient characteristics were compared between the two lymph node groups (lymph node positive and lymph node negative) and significant prognostic factors were determined.
A total of 462 oral squamous cell carcinoma (OSCC) patients were included, 407 male and 55 female. Tobacco chewing (59.2%) was a major habit with buccal mucosa (49.5%) and tongue (44.8%) as primary sites. The majority of the patient's histology was of SCC (96.8%) with grade II (moderately differentiated, 74.5%). Univariate logistic regression analysis to predict lymph node metastasis showed pT size (< 0.001), LVI (< 0.001), and PNI (< 0.001) as significant tumor characteristics. On multivariate, pT size (OR-1.58, - 0.0001) and LVI (OR-19.70, - 0.0001) were reported to be statistically significant to predict lymph node metastasis.
Reporting and studying the clinico-pathological features of primary tumors can give vital information in predicting the neck node metastasis in OSCC patients.
本研究探讨原发性肿瘤的人口统计学和病理学特征在预测早期口腔癌颈部转移中的作用，这一直是一个有争议的问题。
对2014年1月至2021年12月期间在本中心就诊的所有患者进行了一项单中心、回顾性、机构审查。比较了两组淋巴结（淋巴结阳性和淋巴结阴性）患者的特征，并确定了显著的预后因素。
共纳入462例口腔鳞状细胞癌（OSCC）患者，男性407例，女性55例。咀嚼烟草（59.2%）是主要习惯，主要发病部位为颊黏膜（49.5%）和舌（44.8%）。大多数患者的组织学类型为鳞状细胞癌（96.8%），II级（中度分化，74.5%）。预测淋巴结转移的单因素逻辑回归分析显示，pT大小（<0.001）、淋巴管浸润（<0.001）和神经侵犯（<0.001）是显著的肿瘤特征。多因素分析显示，pT大小（OR-1.58，-0.0001）和淋巴管浸润（OR-19.70，-0.0001）对预测淋巴结转移具有统计学意义。
报告和研究原发性肿瘤的临床病理特征可为预测OSCC患者的颈部淋巴结转移提供重要信息。
