Mazidi Mohsen, Gao Hong-Kai, Li Liang, Hui Han
Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Chaoyang, Beijing, China; Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Science (IC-UCAS), Chaoyang, China.
Department of General Surgery, the General Hospital of Chinese People's Armed Police Forces, Beijing, China.
Surgery. 2017 May;161(5):1423-1429. doi: 10.1016/j.surg.2016.11.027. Epub 2017 Feb 21.
To report on the effects of Roux-en-Y gastric bypass operation for obesity on measures of adiposity, insulin secretion and sensitivity, glucose homeostasis, and improvement in diabetic control in Chinese patients.
This was a prospective cohort study of 152 participants (81% with diabetes) who were recruited for bariatric operation.
Mean body mass index was decreased by 18.1% from 30.31 ± 5.38 kg/m at baseline to 24.45 ± 3.79 kg/m at 2 years (P < .001). Indices of insulin secretion, including serum c-peptide (both fasted and at various time points during an oral glucose tolerance test) improved at the 3-year follow-up, with a significant improvement in insulin sensitivity and glucose homeostasis.
The effects of Roux-en-Y gastric bypass 3 years postoperative on adiposity were paralleled by a significant improvement in insulin secretion and sensitivity, and glucose tolerance.
报告在中国患者中，Roux-en-Y胃旁路手术治疗肥胖对肥胖指标、胰岛素分泌与敏感性、葡萄糖稳态及糖尿病控制改善情况的影响。
这是一项对152名参与者（81%患有糖尿病）进行的前瞻性队列研究，这些参与者被招募接受减肥手术。
平均体重指数从基线时的30.31±5.38kg/m²下降了18.1%，至2年时为24.45±3.79kg/m²（P<.001）。胰岛素分泌指标，包括血清C肽（空腹及口服葡萄糖耐量试验期间的各个时间点）在3年随访时有所改善，胰岛素敏感性和葡萄糖稳态也有显著改善。
Roux-en-Y胃旁路手术术后3年对肥胖的影响伴随着胰岛素分泌与敏感性以及葡萄糖耐量的显著改善。
