Mazidi Mohsen, Gao Hong-Kai, Hui Han, Li Liang, Ferns Gordon A
Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Chaoyang, Beijing, China.
Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Science (IC-UCAS), West Beichen Road, Chaoyang, China.
Indian J Gastroenterol. 2017 Jul;36(4):258-262. doi: 10.1007/s12664-017-0774-0. Epub 2017 Aug 5.
We aimed to investigate the changes in adiposity and other cardiometabolic risk factors in the year following Roux-en-Y gastric bypass (RYGB) in patients of Chinese ethnicity.
The study recruited 209 patients who met the indications for bariatric surgery. Adiposity and cardiometabolic risk factors were assessed at baseline and over the 12 months following surgery in all participants. SPSS® software was used for statistical analysis.
The mean body mass index (BMI) was 29.98 kg/m at baseline and steadily decreased to 25.32 kg/m at 12 months, giving a relative change of -15.5% (p < 0.001). All of the lipid profile fractions except high-density lipoprotein (HDL) declined during the first 12 months of follow up; serum HDL increased during this time (all ANOVA p < 0.001). The mean fasting plasma glucose was 9.49 mmol/L at baseline and gradually decreased to 5.69 mmol/L at 12 months, giving a relative change of -40.0% (p < 0.001).
Following the RYGB procedure, changes in measures of adiposity were paralleled by a significant improvement in cardiometabolic factors for 12 months after surgery.
我们旨在研究华裔患者接受Roux-en-Y胃旁路术（RYGB）后一年内肥胖及其他心脏代谢危险因素的变化。
该研究招募了209例符合减肥手术指征的患者。对所有参与者在基线时以及术后12个月内评估肥胖及心脏代谢危险因素。使用SPSS®软件进行统计分析。
基线时平均体重指数（BMI）为29.98kg/m²，12个月时稳步降至25.32kg/m²，相对变化为-15.5%（p<0.001）。在随访的前12个月中，除高密度脂蛋白（HDL）外的所有血脂指标均下降；在此期间血清HDL升高（所有方差分析p<0.001）。基线时平均空腹血糖为9.49mmol/L，12个月时逐渐降至5.69mmol/L，相对变化为-40.0%（p<0.001）。
RYGB手术后，肥胖指标的变化与术后12个月心脏代谢因素的显著改善同时出现。
