Estienne M H, Lepelley P, Zandecki M, Fenaux P, Jouet J P, Ducoulombier P, Le Baron F, Caron B, Chassaing O, Cosson A
Laboratoire d'Hématologie, CHU Lille.
Ann Biol Clin (Paris). 1987;45(4):402-8.
The authors present a cytological study of 200 cases of myelodysplastic syndromes (MDS) [corrected], classified according to the FAB cooperative group. This analysis involves the conventional parameters of the peripheral blood and bone marrow differential counts, the systematic recording of signs of dysmyelopoiesis on the erythroblastic [corrected], granulocytic and megacaryocytic lineages and the assessment of blood granulocytes myeloperoxidase (MPO). On the outside of the typical acquired idiopathic sideroblastic anaemia (severe, isolated anaemia associated with intense dyserythropoiesis), the diagnosis of MDS requires very astute cytological interpretation: indeed, when the dysgranulopoiesis is pronounced, determination of peripheral blood and bone marrow differential count is especially difficult. Conversely when the dysmyelopoiesis is slight, a systematic search of morphology signs [corrected] of its presence must be done and associated with functional studies such as MPO activity technically easy to realize.
作者对200例骨髓增生异常综合征（MDS）[已校正]进行了细胞学研究，这些病例根据FAB协作组进行分类。该分析涉及外周血和骨髓分类计数的常规参数、对红系[已校正]、粒系和巨核系骨髓生成异常体征的系统记录以及对血液粒细胞髓过氧化物酶（MPO）的评估。在典型的获得性特发性铁粒幼细胞贫血（严重的、孤立性贫血伴强烈的红细胞生成异常）之外，MDS的诊断需要非常敏锐的细胞学解释：实际上，当粒细胞生成异常明显时，外周血和骨髓分类计数的测定尤其困难。相反，当骨髓生成异常轻微时，必须系统地寻找其存在的形态学体征[已校正]，并与功能研究如技术上易于实现的MPO活性相关联。
