O'Banion M K, Sundberg J P
Department of Microbiology, School of Life Sciences, University of Illinois, Urbana 61801.
Am J Vet Res. 1987 Oct;48(10):1453-5.
Cutaneous fibromas of white-tailed deer were transmitted successfully to 5 young deer. Serial biopsy specimens of the induced lesions were analyzed for white-tailed deer papillomavirus, using Southern blot hybridization. Viral genomes were found in all specimens taken 1 to 7 weeks after inoculation and, in some cases, from specimens of the inoculation site obtained later. Viral DNA was found before histologic evidence of fibroblast proliferation and persisted in low copy number, compared with viral DNA of naturally developing fibromas.
白尾鹿的皮肤纤维瘤成功传播给了5只幼鹿。使用Southern印迹杂交法对诱导病变的系列活检标本进行白尾鹿乳头瘤病毒分析。在接种后1至7周采集的所有标本中都发现了病毒基因组，在某些情况下，在接种部位后期获得的标本中也发现了病毒基因组。在成纤维细胞增殖的组织学证据出现之前就发现了病毒DNA，并且与自然发生的纤维瘤的病毒DNA相比，其以低拷贝数持续存在。
