Takayanagi I, Karasawa A, Kasuya Y
Eur J Pharmacol. 1978 Jul 15;50(2):137-43. doi: 10.1016/0014-2999(78)90009-2.
Taenia isolated from the guinea pig caecum were used for the experiments. No inhibitory response of the depolarized taenia to isoprenaline was observed during the significant increase of cyclic AMP level. These observations suggest that the total tissue level of cyclic AMP is not an important determinant of relaxation in the depolarized taenia. Antispasmodics, such as papaverine, benactyzine and Aspaminol (1,1-diphenyl-3-piperidino-butanol hydrochloride) relaxed the depolarized taenia, while the depolarized taenia was not relaxed by concentrations of dibutyryl cyclic AMP sufficient to relax the polarized taenia. Ca uptake by the depolarized taenia was inhibited by papaverine, benactyzine and Aspaminol but not by isoprenaline and dibutyryl cyclic AMP. These results indicate that relaxation of the depolarized taenia induced by the antispasmodics used was mainly due to inhibition of Ca uptake.
从豚鼠盲肠分离出的绦虫被用于实验。在环磷酸腺苷（cAMP）水平显著升高期间，未观察到去极化绦虫对异丙肾上腺素的抑制反应。这些观察结果表明，环磷酸腺苷的总组织水平不是去极化绦虫松弛的重要决定因素。解痉药，如罂粟碱、苯那辛和阿斯帕明醇（1,1 - 二苯基 - 3 - 哌啶基 - 丁醇盐酸盐）可使去极化绦虫松弛，而足以使极化绦虫松弛的二丁酰环磷酸腺苷浓度对去极化绦虫却无松弛作用。罂粟碱、苯那辛和阿斯帕明醇可抑制去极化绦虫对钙的摄取，但异丙肾上腺素和二丁酰环磷酸腺苷则无此作用。这些结果表明，所使用的解痉药诱导去极化绦虫松弛主要是由于抑制了钙的摄取。
