非特异性平滑肌松弛剂对豚鼠去极化盲肠带中糖原磷酸化酶活性的影响。

Effects of nonspecific smooth muscle relaxants on glycogen phosphorylase activity in depolarized taenia caecum of guinea pig.

作者信息

Takayanagi I, Karasawa A, Kasuya Y

出版信息

J Pharmacobiodyn. 1980 Jan;3(1):65-7. doi: 10.1248/bpb1978.3.65.

DOI:10.1248/bpb1978.3.65

PMID:7205531

Abstract

Effects of papaverine, Aspaminol (an antispasmodic drug), D-600, 2, 4-dinitrophenol and Ca ions on glycogen phosphorylase activity in the KCl-depolarized taenia caecum of guinea pig were tested. External Ca ions dose-dependently activated phosphorylase, indicating that Ca ions, which entered the smooth muscle cells, played an important role in the regulation of phosphorylase activity. Aspaminol, D-600 and removal of Ca ions from bath fluid inhibited phosphorylase activity. Since these treatments relaxed the taenia caecum, the decrease of phosphorylase activity after the treatments may be mainly due to the decrease of energy consumption. Papaverine and 2, 4-dinitrophenol induced an activation of phosphorylase which might be for replenishment of energy stores decreased by them.

摘要

测试了罂粟碱、阿斯帕米诺（一种解痉药）、D - 600、2,4 - 二硝基苯酚和钙离子对豚鼠氯化钾去极化盲肠条中糖原磷酸化酶活性的影响。细胞外钙离子剂量依赖性地激活磷酸化酶，表明进入平滑肌细胞的钙离子在磷酸化酶活性调节中起重要作用。阿斯帕米诺、D - 600以及从浴液中去除钙离子均抑制磷酸化酶活性。由于这些处理使盲肠条松弛，处理后磷酸化酶活性的降低可能主要是由于能量消耗的减少。罂粟碱和2,4 - 二硝基苯酚诱导磷酸化酶激活，这可能是为了补充被它们降低的能量储备。