Gaur Sonia, Turkbey Baris, Choyke Peter
Molecular Imaging Program, National Cancer Institute, Bethesda, MD; Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA.
Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA.
Semin Ultrasound CT MR. 2017 Feb;38(1):59-71. doi: 10.1053/j.sult.2016.10.002. Epub 2016 Oct 14.
Hereditary renal cancers account for approximately 5%-8% of all renal tumors. Over the past 2 decades, a number of syndromes have been identified that predispose patients to early renal cancer development, representing all the major histologic types of tumor pathology. In this article, we describe the current knowledge concerning the cell type, known mechanism of tumor development, other manifestations of the syndrome, imaging findings, genetic screening, and imaging surveillance recommendations for each of the major syndromes associated with hereditary renal cancers.
遗传性肾癌约占所有肾肿瘤的5%-8%。在过去20年中，已发现一些综合征会使患者易患早期肾癌，涵盖了肿瘤病理学的所有主要组织学类型。在本文中，我们描述了关于与遗传性肾癌相关的每种主要综合征的细胞类型、已知的肿瘤发生机制、综合征的其他表现、影像学检查结果、基因筛查以及影像学监测建议的当前知识。
