Walker Stephanie M, Gautam Rabindra, Turkbey Baris, Malayeri Ashkan, Choyke Peter L
Molecular Imaging Program, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Radiol Clin North Am. 2020 Sep;58(5):951-963. doi: 10.1016/j.rcl.2020.04.003. Epub 2020 Jun 10.
Up to 8% of renal cancers are thought to have a hereditary component. Several hereditary renal cancer syndromes have been identified over the last few decades. It is important for the radiologist to be aware of findings associated with hereditary renal cancer syndromes to detect tumors early, enroll patients in appropriate surveillance programs, and improve outcomes for the patient and affected family members. This review discusses from a radiologist's perspective well-known hereditary renal cancer syndromes and emerging genetic mutations associated with renal cancer that are less well characterized, focusing on imaging features and known associations.
高达8%的肾癌被认为具有遗传因素。在过去几十年中，已经确定了几种遗传性肾癌综合征。对于放射科医生来说，了解与遗传性肾癌综合征相关的表现非常重要，以便早期发现肿瘤，让患者参加适当的监测项目，并改善患者及其受影响家庭成员的治疗效果。本综述从放射科医生的角度讨论了著名的遗传性肾癌综合征以及与肾癌相关但特征尚不明确的新出现的基因突变，重点关注影像学特征和已知关联。
