Lusthof K J, Bosman I J, Kubat B, Vincenten-van Maanen M J
Netherlands Forensic Institute, Laan van Ypenburg 6, 2497 GB Den Haag, The Netherlands.
Netherlands Forensic Institute, Laan van Ypenburg 6, 2497 GB Den Haag, The Netherlands.
Forensic Sci Int. 2017 May;274:79-82. doi: 10.1016/j.forsciint.2017.01.024. Epub 2017 Feb 4.
The use of scopolamine as an incapacitating drug, in sexual crimes and robberies, has been known for many decades. However, blood concentrations and doses of scopolamine in those cases are largely unknown. Here we present the toxicological results of one fatal and two non-fatal cases in a series of scopolamine-facilitated robberies. In the fatal case, the concentration of scopolamine in heart blood was 0.30mg/L, about 3000 times higher than the average therapeutic level of 0.0001mg/L (for one dermal patch). In femoral blood, the concentration of scopolamine was much lower (0.0048mg/L), but still 50 times higher than therapeutic levels. The scopolamine concentration in the stomach was very high (20mg/kg) as compared to the heart blood and femoral blood, which explains the very high concentration in heart blood by postmortem leakage from the stomach. In the non-fatal case, the scopolamine concentration in serum, obtained 23h after the incident, was 0.00035mg/L. The estimated concentration of scopolamine at the time of the incident is 0.0035mg/L. In the other non-fatal case, scopolamine was detected in urine and in hair.
数十年来，人们一直知晓东莨菪碱被用作性犯罪和抢劫案中的使人丧失能力的药物。然而，在这些案件中，东莨菪碱的血药浓度和剂量大多未知。在此，我们呈现了一系列东莨菪碱辅助抢劫案中一起致命案件和两起非致命案件的毒理学结果。在致命案件中，心脏血液中东莨菪碱的浓度为0.30mg/L，约为平均治疗水平0.0001mg/L（一片皮肤贴片的量）的3000倍。在股静脉血液中，东莨菪碱的浓度要低得多（0.0048mg/L），但仍比治疗水平高50倍。与心脏血液和股静脉血液相比，胃中东莨菪碱的浓度非常高（20mg/kg），这解释了心脏血液中高浓度是由于死后胃内容物泄漏所致。在非致命案件中，事件发生23小时后获得的血清中东莨菪碱浓度为0.00035mg/L。事件发生时东莨菪碱的估计浓度为0.0035mg/L。在另一起非致命案件中，在尿液和头发中检测到了东莨菪碱。
