McIntyre Iain M, Mallett Phyllis, Burton Christopher G, Morhaime Jacquelyn
County of San Diego Medical Examiner's Office, 5570 Overland Avenue, Suite 101, San Diego, CA, 92123.
J Forensic Sci. 2014 Nov;59(6):1675-8. doi: 10.1111/1556-4029.12489. Epub 2014 Apr 3.
A woman was found unresponsive with an empty bottle of Cogentin(®) prescribed to another. Admitted to an area hospital, her condition steadily declined until death 29 h after admission. Following toxicological screening on hospital (admission) whole blood, the only significant compound detected was benztropine. Benztropine was confirmed at 0.28 mg/L - the highest antemortem blood concentration recorded in a case of toxicity or fatality uniquely associated with benztropine. A second serum antemortem specimen showed a benztropine concentration of 0.19 mg/L. Despite over 24 h in the hospital, benztropine was also found in the postmortem specimens collected at autopsy. Peripheral blood, central blood, liver, and gastric concentrations were 0.47 mg/L, 0.36 mg/L, 9.6 mg/kg, and 44 mg, respectively. These results indicate that benztropine exhibited a potential difference between whole-blood and serum (plasma) concentrations. Additionally, in consideration of literature data, benztropine was found indicative of a compound prone to at least some postmortem redistribution.
一名女性被发现无反应，身旁有一瓶开给他人的安坦（®）空瓶。她被送往当地一家医院，入院后病情持续恶化，直至入院29小时后死亡。对医院（入院时）全血进行毒理学筛查后，检测到的唯一重要化合物是苯海索。苯海索浓度被确认为0.28毫克/升，这是有记录以来与苯海索单独相关的中毒或死亡病例中最高的生前血药浓度。第二份生前血清样本显示苯海索浓度为0.19毫克/升。尽管在医院治疗超过24小时，但尸检时采集的死后样本中也发现了苯海索。外周血、中心血、肝脏和胃中的浓度分别为0.47毫克/升、0.36毫克/升、9.6毫克/千克和44毫克。这些结果表明苯海索在全血和血清（血浆）浓度之间存在潜在差异。此外，考虑到文献数据，发现苯海索是一种至少会发生一定程度死后再分布的化合物。
