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注意缺陷与反应时间变异性与青少年腹内侧前额叶体积相关。

Inattention and Reaction Time Variability Are Linked to Ventromedial Prefrontal Volume in Adolescents.

机构信息

Department of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont.

Department of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont.

出版信息

Biol Psychiatry. 2017 Nov 1;82(9):660-668. doi: 10.1016/j.biopsych.2017.01.003. Epub 2017 Jan 13.

DOI:10.1016/j.biopsych.2017.01.003
PMID:28237458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5509516/
Abstract

BACKGROUND

Neuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) have most commonly reported volumetric abnormalities in the basal ganglia, cerebellum, and prefrontal cortices. Few studies have examined the relationship between ADHD symptomatology and brain structure in population-based samples. We investigated the relationship between dimensional measures of ADHD symptomatology, brain structure, and reaction time variability-an index of lapses in attention. We also tested for associations between brain structural correlates of ADHD symptomatology and maps of dopaminergic gene expression.

METHODS

Psychopathology and imaging data were available for 1538 youths. Parent ratings of ADHD symptoms were obtained using the Development and Well-Being Assessment and the Strengths and Difficulties Questionnaire (SDQ). Self-reports of ADHD symptoms were assessed using the youth version of the SDQ. Reaction time variability was available in a subset of participants. For each measure, whole-brain voxelwise regressions with gray matter volume were calculated.

RESULTS

Parent ratings of ADHD symptoms (Development and Well-Being Assessment and SDQ), adolescent self-reports of ADHD symptoms on the SDQ, and reaction time variability were each negatively associated with gray matter volume in an overlapping region of the ventromedial prefrontal cortex. Maps of DRD1 and DRD2 gene expression were associated with brain structural correlates of ADHD symptomatology.

CONCLUSIONS

This is the first study to reveal relationships between ventromedial prefrontal cortex structure and multi-informant measures of ADHD symptoms in a large population-based sample of adolescents. Our results indicate that ventromedial prefrontal cortex structure is a biomarker for ADHD symptomatology. These findings extend previous research implicating the default mode network and dopaminergic dysfunction in ADHD.

摘要

背景

注意力缺陷多动障碍（ADHD）的神经影像学研究最常报告基底神经节、小脑和前额皮质的体积异常。很少有研究检查基于人群的样本中 ADHD 症状与大脑结构之间的关系。我们研究了 ADHD 症状的维度测量、大脑结构与反应时变异性（注意力不集中的指标）之间的关系。我们还测试了 ADHD 症状的大脑结构相关性与多巴胺能基因表达图谱之间的关联。

方法

精神病理学和影像学数据可用于 1538 名青少年。ADHD 症状的父母评定采用发育与健康评估和困难问卷（SDQ）进行。青少年自我报告的 ADHD 症状采用 SDQ 的青少年版本进行评估。反应时变异性在部分参与者中可用。对于每个测量值，都进行了全脑体素水平的回归分析，以评估灰质体积。

结果

父母对 ADHD 症状（发育与健康评估和 SDQ）的评定、青少年自我报告的 SDQ 上的 ADHD 症状以及反应时变异性均与腹内侧前额皮质的重叠区域的灰质体积呈负相关。DRD1 和 DRD2 基因表达图谱与 ADHD 症状的大脑结构相关性相关。

结论

这是第一项在大型基于人群的青少年样本中揭示腹内侧前额皮质结构与多指标 ADHD 症状之间关系的研究。我们的研究结果表明，腹内侧前额皮质结构是 ADHD 症状的生物标志物。这些发现扩展了先前关于默认模式网络和多巴胺能功能障碍与 ADHD 相关的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b116/5509516/495e095209ad/nihms862299f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b116/5509516/6fcc807b5d3e/nihms862299f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b116/5509516/d3f1f3fe318c/nihms862299f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b116/5509516/5b65faccaa93/nihms862299f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b116/5509516/0db8da7c6f7a/nihms862299f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b116/5509516/495e095209ad/nihms862299f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b116/5509516/6fcc807b5d3e/nihms862299f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b116/5509516/d3f1f3fe318c/nihms862299f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b116/5509516/5b65faccaa93/nihms862299f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b116/5509516/0db8da7c6f7a/nihms862299f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b116/5509516/495e095209ad/nihms862299f5.jpg

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