Davido B, Batista R, Michelon H, Lepainteur M, Bouchand F, Lepeule R, Salomon J, Vittecoq D, Duran C, Escaut L, Sobhani I, Paul M, Lawrence C, Perronne C, Chast F, Dinh A
Infectious Diseases Unit, Raymond Poincaré Teaching Hospital, APHP, Versailles Saint-Quentin University, Garches, France.
Pharmacy Department, Cochin Teaching Hospital, APHP, Paris Descartes University, Paris, France.
J Hosp Infect. 2017 Apr;95(4):433-437. doi: 10.1016/j.jhin.2017.02.001. Epub 2017 Feb 6.
Carbapenem-resistant Enterobacteriaceae (CRE) or vancomycin-resistant enterococci (VRE) carriage present a major public health challenge. Decolonization strategies are lacking. We aimed to evaluate the impact of faecal microbiota transplantation (FMT) on a cohort of patients with digestive tract colonization by CRE or VRE. Eight patients were included: six carrying CRE and two colonized by VRE. One month after FMT, two patients were free from CRE carriage, and another patient was free from VRE after three months. In our experience, this strategy is safe.
耐碳青霉烯类肠杆菌科细菌（CRE）或耐万古霉素肠球菌（VRE）的携带构成了重大的公共卫生挑战。目前缺乏去定植策略。我们旨在评估粪便微生物群移植（FMT）对一组消化道被CRE或VRE定植患者的影响。纳入了8名患者：6名携带CRE，2名被VRE定植。FMT后1个月，2名患者不再携带CRE，另1名患者在3个月后不再携带VRE。根据我们的经验，该策略是安全的。
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