Gadomska Grażyna, Stankowska Katarzyna, Boinska Joanna, Ślusarz Robert, Tylicka Marzena, Michalska Małgorzata, Jachalska Anna, Rość Danuta
Department of Hematology and Malignant Diseases of Hematopoietic System, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Poland.
Department of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Poland.
Medicina (Kaunas). 2017;53(1):34-39. doi: 10.1016/j.medici.2017.01.004. Epub 2017 Feb 2.
Data from the literature indicate the relationship between the bone marrow microvessel density and the blood parameters of angiogenesis. The aim of this study was to evaluate selected parameters of angiogenesis (VEGF-A, sVEGFR-1, and sVEGFR-2) and their correlations with white blood cells, platelets, and red blood cells.
The study included 72 patients (mean age, 61.84 years) with myeloproliferative neoplasms (MPNs): essential thrombocythemia (ET) (n=46), polycythemia vera (PV) (n=19), and primary myelofibrosis (PMF) (n=7). Serum VEGF-A, sVEGFR-1, and sVEGFR-2 were determined using the ELISA assay.
We observed a significantly higher level of VEGF-A and reduced concentrations of sVEGFR-1 and sVEGFR-2 in the whole group of patients with MPNs as compared to controls. Detailed analysis confirmed significantly higher level of VEGF-A and lower concentration of sVEGFR-2 in each subgroups of MPNs patients. However, sVEGFR-1 concentrations were significantly lower only in PV and ET patients.
The study showed an increased level of VEGF-A, which may indicate the intensity of neoangiogenesis in the bone marrow. Decreased sVEGFR-1 and sVEGFR-2 in the blood of patients with MPNs may reflect consumption of these soluble receptors.
文献数据表明骨髓微血管密度与血管生成的血液参数之间存在关联。本研究的目的是评估血管生成的选定参数（VEGF-A、sVEGFR-1和sVEGFR-2）及其与白细胞、血小板和红细胞的相关性。
该研究纳入了72例骨髓增殖性肿瘤（MPN）患者（平均年龄61.84岁）：原发性血小板增多症（ET）（n = 46）、真性红细胞增多症（PV）（n = 19）和原发性骨髓纤维化（PMF）（n = 7）。采用酶联免疫吸附测定法测定血清VEGF-A、sVEGFR-1和sVEGFR-2。
我们观察到，与对照组相比，MPN患者全组的VEGF-A水平显著更高，sVEGFR-1和sVEGFR-2浓度降低。详细分析证实，MPN患者各亚组的VEGF-A水平显著更高，sVEGFR-2浓度更低。然而，仅PV和ET患者的sVEGFR-1浓度显著更低。
该研究显示VEGF-A水平升高，这可能表明骨髓中新生血管生成的强度。MPN患者血液中sVEGFR-1和sVEGFR-2降低可能反映了这些可溶性受体的消耗。
