Tang K N, Fletcher O J, Villegas P
Tennessee Department of Agriculture, Ellington Agriculture Center, Nashville 37204.
Avian Dis. 1987 Jul-Sep;31(3):584-90.
Reovirus strain 176, isolated from chickens with tenosynovitis, was highly pathogenic following oral inoculation of 1-day-old specific-pathogen-free chicks. Disseminated lesions including hepatic necrosis, splenic lymphostromal cell hyperplasia, and bursal atrophy occurred on day 3 postinoculation (PI), followed by myocarditis on day 6 PI and by pericarditis and tenosynovitis on day 9 PI. Reovirus was isolated from the liver as early as day 1 PI, whereas significant neutralizing antibody was detected on day 13 PI. Mortality occurred from day 4 to day 7 PI, and the death of birds was associated with the severity of hepatic necrosis. The occurrence of tenosynovitis in virus-inoculated birds was subclinical.
从患有腱鞘炎的鸡中分离出的呼肠孤病毒176株，经口接种1日龄无特定病原体雏鸡后具有高度致病性。接种后第3天（PI）出现包括肝坏死、脾淋巴基质细胞增生和法氏囊萎缩在内的播散性病变，随后在接种后第6天出现心肌炎，在接种后第9天出现心包炎和腱鞘炎。早在接种后第1天就从肝脏中分离出呼肠孤病毒，而在接种后第13天检测到显著的中和抗体。死亡率在接种后第4天至第7天出现，禽类死亡与肝坏死的严重程度有关。接种病毒的禽类中腱鞘炎的发生为亚临床症状。
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