Gates L S, Leyland K M, Sheard S, Jackson K, Kelly P, Callahan L F, Pate R, Roos E M, Ainsworth B, Cooper C, Foster C, Newton J L, Batt M E, Arden N K
Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis, University of Oxford, Oxford, UK.
Faculty of Health Sciences, University of Southampton, Southampton, UK.
Rheumatol Int. 2017 Apr;37(4):469-478. doi: 10.1007/s00296-017-3672-y. Epub 2017 Feb 25.
Physical activity (PA) is increasingly recognised as an important factor within studies of osteoarthritis (OA). However, subjective methods used to assess PA are highly variable and have not been developed for use within studies of OA, which creates difficulties when comparing and interpreting PA data in OA research. The aim of this study was, therefore, to gain expert agreement on the appropriate methods to harmonise PA data among existing population cohorts to enable the investigation of the association of PA and OA. The definition of PA in an OA context and methods of harmonization were established via an international expert consensus meeting and modified Delphi exercise using a geographically diverse committee selected on the basis of individual expertise in physical activity, exercise medicine, and OA. Agreement was met for all aims of study: (1) The use of Metabolic Equivalent of Task (MET) minutes per week (MET-min/week) as a method for harmonising PA variables among cohorts; (2) The determination of methods for treating missing components of MET-min/week calculation; a value will be produced from comparable activities within a representative cohort; (3) Exclusion of the domain of occupation from total MET-min/week; (4) The need for a specific measure of joint loading of an activity in addition to intensity and time, in studies of diseases, such as OA. This study has developed a systematic method to classify and harmonise PA in existing OA cohorts. It also provides minimum requirements for future studies intending to include subjective PA measures.
体力活动（PA）在骨关节炎（OA）研究中日益被视为一个重要因素。然而，用于评估PA的主观方法差异很大，且尚未针对OA研究进行开发，这在比较和解释OA研究中的PA数据时造成了困难。因此，本研究的目的是就适当的方法达成专家共识，以协调现有队列人群中的PA数据，从而能够研究PA与OA之间的关联。通过国际专家共识会议和改良的德尔菲法，利用一个基于体力活动、运动医学和OA方面的个人专业知识挑选出来的具有地域多样性的委员会，确定了OA背景下PA的定义和协调方法。研究的所有目标均达成了共识：（1）使用每周代谢当量任务（MET）分钟数（MET-分钟/周）作为协调队列间PA变量的方法；（2）确定处理MET-分钟/周计算中缺失部分的方法；将从代表性队列中的可比活动得出一个值；（3）将职业领域排除在总MET-分钟/周之外；（4）在诸如OA等疾病的研究中，除强度和时间外，还需要对活动的关节负荷进行特定测量。本研究开发了一种系统方法，用于对现有OA队列中的PA进行分类和协调。它还为未来打算纳入主观PA测量的研究提供了最低要求。
