Gao Na, Wang Xue-Xia, Sun Jian-Rong, Yu Wen-Zheng, Li Xi-Zhi
Department of hematology, Binzhou Medical University Hospital, Binzhou, Shandong, China.
Department of nephrology, Binzhou Medical University Hospital, Binzhou, Shandong, China.
Ann Hematol. 2017 May;96(5):711-718. doi: 10.1007/s00277-017-2948-3. Epub 2017 Feb 25.
Increased galectin-3 expression has been currently showed to be associated with poor prognosis in some hematological malignancies, such as acute myeloid leukemia, diffuse large B cell lymphoma. However, little is known about the clinical significance of galectin-3 in patients with acute promyelocytic leukemia (APL). We investigated the concentration of serum galectin-3 and characterized the relationship between galectin-3 and outcome in patients with APL. Higher galectin-3 levels were detected in patients with APL compared with the healthy controls (p < 0.001). Higher galectin-3 levels were closely associated with older ages (p < 0.001), the medical history of psoriasis (p = 0.036), coagulopathy (p = 0.042), and CD34 expression (p = 0.004). Compared with patients with lower galectin-3 levels, those with higher galectin-3 levels had significant shorter overall survival (p = 0.028) and relapse-free survival (p = 0.001). Multivariate analysis showed that serum galectin-3 was an independent unfavorable factor for relapse-free survival in patients with APL treated with all-trans retinoic acid and arsenic trioxide-based frontline therapy. Clinical impact of galectin-3 should be further investigated in patients with APL.
目前研究表明，在一些血液系统恶性肿瘤，如急性髓系白血病、弥漫性大B细胞淋巴瘤中，半乳糖凝集素-3表达增加与预后不良相关。然而，关于半乳糖凝集素-3在急性早幼粒细胞白血病（APL）患者中的临床意义知之甚少。我们研究了APL患者血清半乳糖凝集素-3的浓度，并明确了半乳糖凝集素-3与APL患者预后之间的关系。与健康对照组相比，APL患者的血清半乳糖凝集素-3水平更高（p<0.001）。较高的半乳糖凝集素-3水平与高龄（p<0.001）、银屑病史（p=0.036）、凝血病（p=0.042）及CD34表达（p=0.004）密切相关。与半乳糖凝集素-3水平较低的患者相比，水平较高的患者总生存期（p=0.028）和无复发生存期显著缩短（p=0.001）。多因素分析显示，对于接受全反式维甲酸和三氧化二砷一线治疗的APL患者，血清半乳糖凝集素-3是无复发生存的独立不良因素。APL患者中半乳糖凝集素-3的临床影响有待进一步研究。
