含LY6/PLAUR结构域蛋白3在维持结直肠癌干细胞样细胞中发挥作用。
LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells.
作者信息
Wang Liming, Hirohashi Yoshihiko, Ogawa Tadashi, Shen Min, Takeda Rui, Murai Aiko, Yamamoto Eri, Kubo Terufumi, Nakatsugawa Munehide, Kanaseki Takayuki, Tsukahara Tomohide, Nishidate Toshihiko, Okita Kenji, Kutomi Goro, Sato Noriyuki, Takemasa Ichiro, Torigoe Toshihiko
机构信息
Department of Pathology, Sapporo Medical University School of Medicine, South-1 West-17, Chuo-Ku, Sapporo 060-8556, Japan; Department of Surgery, Sapporo Higashi Tokusyukai Hospital, North-33 East-14, Higashi-Ku, Sapporo 065-0033, Japan.
Department of Pathology, Sapporo Medical University School of Medicine, South-1 West-17, Chuo-Ku, Sapporo 060-8556, Japan.
出版信息
Biochem Biophys Res Commun. 2017 Apr 29;486(2):232-238. doi: 10.1016/j.bbrc.2017.02.112. Epub 2017 Feb 24.
Colorectal carcinoma (CRC) is one of the most frequently diagnosed cancers and the leading cause of cancer-related death for both men and women. Recent studies have revealed that a small sub-population of cancer cells, termed cancer stem-like cells (CSCs)/cancer-initiating cells (CICs), are endowed with tumor-initiating ability, self-renewal ability and differentiation ability. CSCs/CICs are resistant to current therapies including chemotherapy and radiotherapy. Thus, CSCs/CICs are responsible for recurrence and metastasis, and eradication of CSCs/CICs is essential to cure cancer. In this study, we isolated CR-CSCs/CICs as sphere-cultured cells and found that a product derived from LY6/PLAUR domain containing 3 (LYPD3) is preferentially expressed in CSCs/CICs. Gene overexpression and gene knockdown experiments revealed that LYPD3 has a role in the maintenance of CR-CSCs/CICs. The findings provide a novel molecular insight into CR-CSCs/CICs.
结直肠癌（CRC）是最常被诊断出的癌症之一，也是男性和女性癌症相关死亡的主要原因。最近的研究表明，一小部分癌细胞，即所谓的癌症干细胞样细胞（CSCs）/癌症起始细胞（CICs），具有肿瘤起始能力、自我更新能力和分化能力。CSCs/CICs对包括化疗和放疗在内的当前疗法具有抗性。因此，CSCs/CICs是复发和转移的原因，根除CSCs/CICs对于治愈癌症至关重要。在本研究中，我们将CR-CSCs/CICs分离为球状体培养细胞，并发现一种源自含LY6/PLAUR结构域3（LYPD3）的产物在CSCs/CICs中优先表达。基因过表达和基因敲低实验表明，LYPD3在维持CR-CSCs/CICs方面发挥作用。这些发现为CR-CSCs/CICs提供了新的分子见解。
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