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三级医疗中心破裂性肾下主动脉瘤的血管内修复与开放修复

Endovascular and Open Repair of Ruptured Infrarenal Aortic Aneurysms at a Tertiary Care Center.

作者信息

Schechter Matthew A, Pascarella Luigi, Thomas Steven, McCann Richard L, Mureebe Leila

机构信息

Department of Surgery, Duke University Medical Center, Durham, NC.

Department of Surgery, Duke University Medical Center, Durham, NC.

出版信息

Ann Vasc Surg. 2017 May;41:83-88. doi: 10.1016/j.avsg.2016.10.037. Epub 2017 Feb 24.

Abstract

BACKGROUND

The mortality of ruptured abdominal aortic aneurysms (rAAAs) has been reported as high as 90%. Loss of consciousness and a systolic blood pressure of <80 mm Hg on presentation are the most important predictors of mortality after emergent open repair (OR). Endovascular repair of abdominal aortic aneurysm (EVAR) has reduced short-term operative mortality and morbidity for elective abdominal aortic aneurysm repair, and may be advocated for wider application of EVAR for rAAA. The objective of this study is to compare our experience with OR and EVAR management of rAAA.

METHODS

Retrospective review of all rAAAs presenting to a tertiary care center between January 1, 2000 and December 31, 2011 was performed. Patients were grouped based on the surgical approach (OR versus EVAR). Patient demographics, intraoperative details, and postoperative mortality and morbidity rates were compared. Statistical analyses were conducted with Stata, version 12.

RESULTS

One hundred twenty-six patients presented with rAAA over the study period. Patients who declined repair (n = 14) or died before repair (n = 13) were excluded from this study. Of the 99 patients who underwent repair, 25 patients (25.3%) received EVAR and 74 (74.7%) underwent OR. One patient required conversion to OR from EVAR (1.0%). Overall, 30-day and 1-year mortality was 35.4% and 41.4%, respectively, with no difference seen between the 2 types of repair (30-day mortality: EVAR = 24.0%, OR = 39.2%, P = 0.17; 1-year mortality: EVAR = 32.0%, OR = 44.6%, P = 0.27). Major morbidity also did not differ between the 2 repair procedures (EVAR = 60.0%, OR = 60.8%, P = 0.94). However, patients undergoing EVAR had significantly less estimated blood loss (median: 0.3 vs. 3.0 L, P < 0.0001) and transfusion requirement (median: 5.0 vs. 9.0 U, P = 0.0041). Furthermore, although there was no significant difference in length of overall hospital stay between the 2 groups (8.5 vs. 15 days in the OR group, P = 0.18), significantly more patients in the EVAR group were discharged to home (66.7% vs. 57.1% in the OR group, P = 0.03).

CONCLUSIONS

In contrast to recently published series, this series shows no differences in morbidity or mortality between EVAR or OR of rAAAs. EVAR is appropriate in stable patients with a rAAA and favorable anatomy.

摘要

背景

据报道,破裂性腹主动脉瘤(rAAA)的死亡率高达90%。就诊时意识丧失和收缩压<80 mmHg是急诊开放修复(OR)后死亡率的最重要预测因素。腹主动脉瘤腔内修复术(EVAR)降低了择期腹主动脉瘤修复的短期手术死亡率和发病率,对于rAAA,可能提倡更广泛地应用EVAR。本研究的目的是比较我们在rAAA的OR和EVAR治疗方面的经验。

方法

对2000年1月1日至2011年12月31日期间在一家三级医疗中心就诊的所有rAAA患者进行回顾性分析。根据手术方式(OR与EVAR)对患者进行分组。比较患者的人口统计学特征、术中细节以及术后死亡率和发病率。使用Stata 12版进行统计分析。

结果

在研究期间,有126例患者出现rAAA。拒绝修复(n = 14)或在修复前死亡(n = 13)的患者被排除在本研究之外。在接受修复的99例患者中,25例(25.3%)接受了EVAR,74例(74.7%)接受了OR。1例患者需要从EVAR转为OR(1.0%)。总体而言,30天和1年死亡率分别为35.4%和41.4%,两种修复方式之间无差异(30天死亡率:EVAR = 24.0%,OR = 39.2%,P = 0.17;1年死亡率:EVAR = 32.0%,OR = 44.6%,P = 0.27)。两种修复手术的主要发病率也无差异(EVAR = 60.0%,OR = 60.8%,P = 0.94)。然而,接受EVAR的患者估计失血量明显较少(中位数:0.3 vs. 3.0 L,P < 0.0001),输血需求也较少(中位数:5.0 vs. 9.0 U,P = 0.0041)。此外,尽管两组之间的总住院时间无显著差异(OR组为8.5天 vs. 15天,P = 0.18),但EVAR组出院回家的患者明显更多(66.7% vs. OR组的57.1%,P = 0.03)。

结论

与最近发表的系列研究不同,本系列研究表明rAAA的EVAR或OR在发病率或死亡率方面无差异。EVAR适用于病情稳定、解剖结构有利的rAAA患者。

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