Sarac Timur P, Bannazadeh Mohsen, Rowan A F, Bena James, Srivastava Sunita, Eagleton Mathew, Lyden Sean, Clair Daniel G, Kashyap Vikram
Department of Vascular Surgery, Cleveland Clinic Lerner School of Medicine, Cleveland Clinic, Cleveland, OH, USA.
Ann Vasc Surg. 2011 May;25(4):461-8. doi: 10.1016/j.avsg.2010.12.030.
The continued success of elective endovascular aneurysm repair (EVAR) has led to an extension of this technology to ruptured aortas. The purpose of this study was to evaluate our results of ruptured infrarenal aortic aneurysm (rAAA).
The treatment results of all patients who underwent repair of rAAAs between January 1990 and May 2008 were reviewed retrospectively. Comorbidities, intraoperative details, and postoperative complications were tabulated. EVAR and open repair were compared.
Between January 1990 and May 2008, 160 patients underwent repair of rAAA. Of these, 32 (20%) underwent EVAR for rAAA; of 160 patients, 112 were considered to have free rupture (70%) and 48 had contained rupture (30%). The average Acute Physiology and Chronic Health Evaluation II score was 13.3 ± 6.7. The Kaplan-Meier survival rates at 30 days, 6 months, 1 year, and 5 years were 69% (62,77), 57% (50,65), 50% (43,59), and 25% (19,34), respectively, with no difference seen in EVAR group as compared with open surgery (p = 0.24). Intraoperative mortality was 5.6%, with no patient undergoing EVAR suffering an intraoperative death (p = 0.03). However, 30-day mortality was 31.9% with no difference between EVAR and open surgery (31.2% vs. 32%; p = 0.93) results. Multivariate analysis for 30-day mortality found renal insufficiency (RI) odds ratio (OR): 2.4 (1.1, 5.3), p = 0.04; hypotension OR: 2.4 (1.1, 5.3), p = 0.02; and cardiac arrest OR: 3.8 (1.1, 11.6, p = 0.03), were all associated with the greatest mortality. Of all predictors analyzed, multivariate analysis found preoperative RI OR: 2.32 (1.55, 3.47), p < 0.001, was the only independent predictor of decreased long-term survival.
Mortality rates for rAAA remain high. The use of EVAR for these procedures equals that for open repair with regard to 30-day and long-term mortality. Preoperative cardiac arrest and RI were associated with inferior results for both EVAR and open repair. Clinical judgment on when to use EVAR as a primary repair modality must be exercised.
选择性血管内动脉瘤修复术(EVAR)的持续成功促使该技术扩展至破裂主动脉。本研究旨在评估我们对肾下型破裂主动脉瘤(rAAA)的治疗结果。
回顾性分析1990年1月至2008年5月期间所有接受rAAA修复术患者的治疗结果。将合并症、术中细节及术后并发症制成表格。比较EVAR和开放修复术。
1990年1月至2008年5月,160例患者接受rAAA修复术。其中,32例(20%)接受rAAA的EVAR治疗;160例患者中,112例被认为是自由破裂(70%),48例为局限性破裂(30%)。急性生理与慢性健康状况评分II的平均值为13.3±6.7。30天、6个月、1年和5年的Kaplan-Meier生存率分别为69%(62,77)、57%(50,65)、50%(43,59)和25%(19,34),EVAR组与开放手术组相比无差异(p = 0.24)。术中死亡率为5.6%,接受EVAR治疗的患者无术中死亡(p = 0.03)。然而,30天死亡率为31.9%,EVAR与开放手术组之间无差异(31.2%对32%;p = 0.93)。对30天死亡率的多因素分析发现,肾功能不全(RI)的优势比(OR):2.4(1.1,5.3),p = 0.04;低血压OR:2.4(1.1,5.3),p = 0.02;心脏骤停OR:3.8(1.1,11.6,p = 0.03),均与最高死亡率相关。在所有分析的预测因素中,多因素分析发现术前RI的OR:2.32(1.55,3.47),p < 0.001,是长期生存率降低的唯一独立预测因素。
rAAA的死亡率仍然很高。在30天和长期死亡率方面,这些手术采用EVAR与开放修复相当。术前心脏骤停和RI与EVAR及开放修复的不良结果相关。必须对何时将EVAR用作主要修复方式进行临床判断。