禽肉瘤病毒转化的鸡和大鼠细胞中前病毒的甲基化状态。
The methylation state of the proviruses in avian sarcoma virus transformed chick and rat cells.
作者信息
Roguel N, Moskowitz H, Relevy H, Hamburger J, Kotler M
机构信息
Department of Molecular Genetics, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
出版信息
Biochim Biophys Acta. 1987 Nov 20;910(2):116-22. doi: 10.1016/0167-4781(87)90063-7.
The endogenous viruses in the avian cells are not completely methylated, nor are the Schmidt-Ruppin RSV-D (SRD) proviruses in the infected cells completely unmethylated. Avian sarcoma proviruses integrated in rat transformed cloned cells are heavily methylated. In these cells, a region in the 3' end of the env gene is unmethylated in all the src-containing proviruses but not in the transformed defective (td) proviruses. A possible role for the hypomethylation of the 3' end of the env region is proposed.
禽类细胞中的内源性病毒并非完全甲基化，受感染细胞中的施密特-鲁平罗氏肉瘤病毒D（SRD）前病毒也并非完全未甲基化。整合到大鼠转化克隆细胞中的禽肉瘤前病毒高度甲基化。在这些细胞中，env基因3'端的一个区域在所有含src的前病毒中未甲基化，但在转化缺陷（td）前病毒中甲基化。文中提出了env区域3'端低甲基化的可能作用。
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