The methylation state of the proviruses in avian sarcoma virus transformed chick and rat cells.
作者信息
Roguel N, Moskowitz H, Relevy H, Hamburger J, Kotler M
机构信息
Department of Molecular Genetics, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
出版信息
Biochim Biophys Acta. 1987 Nov 20;910(2):116-22. doi: 10.1016/0167-4781(87)90063-7.
PMID:2823897
Abstract
The endogenous viruses in the avian cells are not completely methylated, nor are the Schmidt-Ruppin RSV-D (SRD) proviruses in the infected cells completely unmethylated. Avian sarcoma proviruses integrated in rat transformed cloned cells are heavily methylated. In these cells, a region in the 3' end of the env gene is unmethylated in all the src-containing proviruses but not in the transformed defective (td) proviruses. A possible role for the hypomethylation of the 3' end of the env region is proposed.
摘要
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