交感神经刺激期间内源性ATP的释放。
Release of endogenous ATP during sympathetic nerve stimulation.
作者信息
Lew M J, White T D
机构信息
Baker Medical Research Institute, Prahran, Victoria, Australia.
出版信息
Br J Pharmacol. 1987 Oct;92(2):349-55. doi: 10.1111/j.1476-5381.1987.tb11330.x.
Abstract
1 Vas deferens from guinea-pig was stimulated with a suction electrode and both contractions and release of endogenous ATP monitored 2 Release of ATP was tetrodotoxin-sensitive and increased when the number of stimuli was increased. 3 Release of ATP was not due to contraction of the muscle and persisted following block of contractions with prazosin and alpha, beta-methylene ATP. 4 These results indicate that stimulation of the sympathetic nerves in the vas deferens releases endogenous ATP presynaptically, supporting a cotransmitter function for ATP with noradrenaline.
摘要
1 用吸力电极刺激豚鼠的输精管，并监测收缩情况以及内源性ATP的释放。2 ATP的释放对河豚毒素敏感，且当刺激次数增加时会增加。3 ATP的释放并非由于肌肉收缩所致，在用哌唑嗪和α,β-亚甲基ATP阻断收缩后仍持续存在。4 这些结果表明，刺激输精管中的交感神经会在突触前释放内源性ATP，支持ATP与去甲肾上腺素具有共同递质功能。
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本文引用的文献
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Tetrodotoxin-resistant release of ATP from guinea-pig taenia coli and vas deferens during electrical field stimulation in the presence of luciferin-luciferase.在荧光素 - 荧光素酶存在的情况下，电场刺激期间豚鼠结肠带和输精管中ATP的河豚毒素抗性释放。
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Discrete events measure single quanta of adenosine 5'-triphosphate secreted from sympathetic nerves of guinea-pig and mouse vas deferens.离散事件测量从豚鼠和小鼠输精管交感神经分泌的三磷酸腺苷的单个量子。
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