Gabbatore Ilaria, Bosco Francesca M, Geda Elisabetta, Gastaldo Luigi, Duca Sergio, Costa Tommaso, Bara Bruno G, Sacco Katiuscia
Faculty of Humanities, Research Unit of Logopedics, Child Language Research Center, University of Oulu, Oulu, Finland; Center for Cognitive Science (CSC), University and Polytechnic of Turin, Turin, Italy.
Center for Cognitive Science (CSC), University and Polytechnic of Turin, Turin, Italy; Department of Psychology, University of Turin, Turin, Italy; Neuroscience Institute of Turin, Turin, Italy.
Neural Plast. 2017;2017:1612078. doi: 10.1155/2017/1612078. Epub 2017 Jan 23.
The present study was intended to evaluate the effects of a rehabilitative training, the Cognitive Pragmatic Treatment (CPT), aimed at improving communicative-pragmatic abilities and the related cognitive components, on the cerebral modifications of a single case patient diagnosed with schizophrenia. The patient underwent two functional magnetic resonance imaging (fMRI) sessions, before and after the treatment. In order to assess brain changes, we calculated the Amplitude of Low Frequency Fluctuation (ALFF) index of the resting-state fMRI signal, which is interpreted as reflecting the intensity of the spontaneous regional activity of the brain. Behavioural measures of the patient's communicative performance were also gathered before and after training and at follow-up. The patient improved his communicative performance in almost all tests. Posttraining stronger ALFF signal emerged in the superior, inferior, and medial frontal gyri, as well as the superior temporal gyri. Even if based on a single case study, these preliminary results show functional changes at the cerebral level that seem to support the patient's behavioural improvements.
本研究旨在评估一种康复训练——认知语用治疗（CPT），该训练旨在改善一名被诊断为精神分裂症的单病例患者的交流语用能力及相关认知成分，对其大脑改变的影响。该患者在治疗前后接受了两次功能磁共振成像（fMRI）检查。为了评估大脑变化，我们计算了静息态fMRI信号的低频振幅（ALFF）指数，该指数被解释为反映大脑自发区域活动的强度。在训练前后及随访时还收集了患者交流表现的行为测量数据。患者在几乎所有测试中交流表现都有所改善。训练后，额上回、额中回、额下回以及颞上回出现了更强的ALFF信号。即使基于单病例研究，这些初步结果也显示出大脑水平的功能变化，似乎支持了患者行为上的改善。
