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低频振幅（ALFF）可能与精神分裂症认知障碍有关：一项相关性研究。

Amplitude of low-frequency fluctuation (ALFF) may be associated with cognitive impairment in schizophrenia: a correlation study.

机构信息

Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People's Republic of China.

Brain Function Research Section, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People's Republic of China.

出版信息

BMC Psychiatry. 2019 Jan 17;19(1):30. doi: 10.1186/s12888-018-1992-4.

DOI:10.1186/s12888-018-1992-4
PMID:30654778
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6337807/
Abstract

BACKGROUND

Cognitive impairments are prominent in schizophrenia (SZ). Imaging studies have demonstrated that functional changes of several areas of the brain exist in SZ patients. The relationships between these two indexes are largely unexplored in SZ. The MATRICS Consensus Cognitive Battery (MCCB) was used to measure cognitive impairment in multi-dimensional cognitive fields of SZ patients. This study was conducted to explore the relationship between cognitive functional impairment and the amplitude of low-frequency fluctuation (ALFF) in SZ patients.

METHOD

A total of 104 participants (44 SZ patients and 60 age- and gender-matched healthy controls (HC)) were recruited for this study. The MCCB was used to assess cognitive function of the participants, while brain activity was assessed using the ALFF. The relationship between the MCCB and the ALFF was investigated by using a correlation analysis.

RESULTS

There were significant differences between SZ patients and HC in MCCB total and domain scores as well as in ALFF results. The reduction of ALFF in the bilateral postcentral gyri and paracentral lobule in SZ patients has a negative correlation with the MCCB sub-test of symbol coding.

CONCLUSION

These findings suggest that the reduction of ALFF in bilateral postcentral gyri and paracentral lobule may be related to cognitive impairment in SZ patients.

摘要

背景

认知障碍在精神分裂症（SZ）中较为突出。影像学研究表明，SZ 患者的大脑多个区域存在功能变化。SZ 患者这两个指标之间的关系在很大程度上尚未得到探索。MATRICS 共识认知电池（MCCB）用于测量 SZ 患者多维认知领域的认知障碍。本研究旨在探讨 SZ 患者认知功能障碍与低频振幅（ALFF）之间的关系。

方法

本研究共纳入 104 名参与者（44 名 SZ 患者和 60 名年龄和性别匹配的健康对照者（HC））。采用 MCCB 评估参与者的认知功能，采用 ALFF 评估大脑活动。通过相关性分析研究 MCCB 和 ALFF 之间的关系。

结果

SZ 患者与 HC 在 MCCB 总分和各领域得分以及 ALFF 结果方面存在显著差异。SZ 患者双侧中央后回和旁中央小叶的 ALFF 减少与 MCCB 符号编码子测试呈负相关。

结论

这些发现表明，双侧中央后回和旁中央小叶的 ALFF 减少可能与 SZ 患者的认知障碍有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1d/6337807/a698c3bde6bb/12888_2018_1992_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1d/6337807/461fc1e54dad/12888_2018_1992_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1d/6337807/a4118870c842/12888_2018_1992_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1d/6337807/4c10504214a5/12888_2018_1992_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1d/6337807/a698c3bde6bb/12888_2018_1992_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1d/6337807/461fc1e54dad/12888_2018_1992_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1d/6337807/a4118870c842/12888_2018_1992_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1d/6337807/4c10504214a5/12888_2018_1992_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1d/6337807/a698c3bde6bb/12888_2018_1992_Fig4_HTML.jpg

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