不同哺乳动物前脑[125I]博尔顿-亨特神经肽Y结合位点的比较。
Comparison of [125I]Bolton-Hunter neuropeptide Y binding sites in the forebrain of various mammalian species.
作者信息
Martel J C, St-Pierre S, Bédard P J, Quirion R
机构信息
Douglas Hospital Research Centre, Department of Psychiatry, Verdun, Que., Canada.
出版信息
Brain Res. 1987 Sep 1;419(1-2):403-7. doi: 10.1016/0006-8993(87)90617-2.
The forebrain distribution of [125I]Bolton-Hunter (BH) neuropeptide Y (NPY) binding sites was compared in 4 mammalian species including rat, hamster, guinea pig and monkey. In all species studied, high densities of [125I]BH NPY binding sites were observed in the hippocampus. In this structure, [125I]BH NPY binding sites were distributed in a laminar fashion, with high densities seen in the oriens layer and stratum radiatum. However, species differences were seen in certain brain areas such as striatum, septum, thalamus and hypothalamus. These differences should be taken into account when studying central effects of neuropeptide Y.
比较了[125I]博尔顿-亨特（BH）神经肽Y（NPY）结合位点在大鼠、仓鼠、豚鼠和猴子这4种哺乳动物前脑的分布情况。在所研究的所有物种中，海马体中均观察到高密度的[125I]BH NPY结合位点。在该结构中，[125I]BH NPY结合位点呈层状分布，在海马伞层和辐射层中密度较高。然而，在某些脑区如纹状体、隔区、丘脑和下丘脑可观察到物种差异。在研究神经肽Y的中枢效应时应考虑这些差异。
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