Nikitin V P, Solntseva S V, Kozyrev S A
P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russian Federation.
Bull Exp Biol Med. 2017 Feb;162(4):413-417. doi: 10.1007/s10517-017-3628-y. Epub 2017 Feb 27.
Experiments were performed on the snails trained in conditioned food aversion for 3 days. Injection of TDZD-8 (glycogen synthase kinase-3 inhibitor, 2 mg/kg) in combination with reminder (presentation of a conditioned food stimulus) led to memory impairment developing 3 days after inhibitor/reminder exposure and followed by spontaneous recovery in 10 days. Injections of TDZD-8 in a dose of 4 or 20 mg/kg before reminder were shown to cause amnesia that persisted for more than 10 days. Memory recovery during repeated training was observed at the earlier period than after initial training. The impairment of memory reconsolidation by TDZD-8 after training of snails for 1 day was less pronounced than under standard training conditions (3 days). The effect of a glycogen synthase kinase-3 inhibitor during memory reconsolidation is probably followed by impairment of memory retrieval and/or partial loss, which can be compensated spontaneously or after repeated training.
对经过3天条件性食物厌恶训练的蜗牛进行了实验。注射TDZD - 8（糖原合酶激酶 - 3抑制剂，2毫克/千克）并结合提示（呈现条件性食物刺激）会导致在抑制剂/提示暴露3天后出现记忆损伤，随后在10天内自发恢复。在提示前注射4或20毫克/千克剂量的TDZD - 8会导致持续超过10天的失忆。在重复训练期间观察到记忆恢复比初次训练后更早出现。蜗牛经过1天训练后，TDZD - 8对记忆重新巩固的损害不如在标准训练条件下（3天）明显。糖原合酶激酶 - 3抑制剂在记忆重新巩固过程中的作用可能会导致记忆提取受损和/或部分丧失，这可以自发补偿或在重复训练后得到补偿。
