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Cocaine stimulates adrenocorticotropin (ACTH) secretion through a corticotropin-releasing factor (CRF)-mediated mechanism.

作者信息

Rivier C, Vale W

机构信息

Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, CA 92037.

出版信息

Brain Res. 1987 Oct 6;422(2):403-6. doi: 10.1016/0006-8993(87)90953-x.

DOI:10.1016/0006-8993(87)90953-x
PMID:2823980
Abstract

Cocaine was injected intravenously to non-anesthetized, freely moving adult male rats and caused dose-dependent elevations in plasma adrenocorticotropin (ACTH) levels. The observation that this stimulatory effect was completely abolished by pretreatment with a corticotropin-releasing factor (CRF) antiserum, coupled with the lack of effect of cocaine on ACTH secretion by cultured pituitary cells, suggests that cocaine acts within the brain to release endogenous CRF.

摘要

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