Cascio C S, Shinsako J, Dallman M F
Department of Physiology, University of California School of Medicine, San Francisco 94143.
Brain Res. 1987 Oct 13;423(1-2):173-8. doi: 10.1016/0006-8993(87)90837-7.
The effect of bilateral lesions of the suprachiasmatic nuclei (SCN) on the circadian rhythm in ACTH was studied in rats that were adrenalectomized and implanted with a subcutaneous corticosterone (B) pellet. Rats wee chronically cannulated to allow for repeated blood sampling. In rats with B pellets, bilateral lesions of the SCN eliminated the circadian rise in plasma ACTH seen in sham-lesioned animals. This is consistent with the idea that the SCN stimulate ACTH secretion in the evening.
在切除肾上腺并皮下植入皮质酮（B）微丸的大鼠中，研究了视交叉上核（SCN）双侧损伤对促肾上腺皮质激素（ACTH）昼夜节律的影响。大鼠长期留置插管以便反复采血。在植入B微丸的大鼠中，SCN双侧损伤消除了假手术动物中出现的血浆ACTH昼夜升高。这与SCN在傍晚刺激ACTH分泌的观点一致。
