中国人群中lncRNA-SOX2OT基因多态性与乳腺癌易感性的相关性
Correlations between lncRNA-SOX2OT polymorphism and susceptibility to breast cancer in a Chinese population.
作者信息
Tang Xiuwu, Gao Yan, Yu Linxiang, Lu Yan, Zhou Guanglin, Cheng Lifang, Sun Kai, Zhu Baoli, Xu Ming, Liu Jingjing
机构信息
Department of Gynecology & Obstetrics, the First Affiliated Hospital of Soochow University, Suzhou, China.
Institute of Suzhou Biobank, Suzhou Center for Disease Prevention & Control, Suzhou, Jiangsu, China.
出版信息
Biomark Med. 2017 Mar;11(3):277-284. doi: 10.2217/bmm-2016-0238. Epub 2017 Feb 17.
AIM
We evaluated the effect of lncRNA SOX2OT expression and its SNP in tumorigenesis and development of breast cancer (BC) in a case-control study.
METHODS
A total of 1106 individuals, 505 newly diagnosed BC patients and 601 age-matched controls (±2 years) were testified. Real-time PCR was adopted for testing tissues' SOX2OT expression. Genotyping of rs9839776 were conducted by using SNaPshot assays.
RESULTS
SOX2OT were overexpressed in BC tissues (p < 0.001). SOX2OT SNP rs9839776 was strongly associated with the higher expression of SOX2OT and an increased risk of BC in Chinese women (odds ratio: 1.42; 95% CI: 1.06-1.90; p = 0.018).
CONCLUSION
These results confirmed that BC was conspicuously associated with higher SOX2OT expression. SOX2OT SNP rs9839776 was significantly associated with the onset of BC possibly via influencing the expression of SOX2OT.
目的
在一项病例对照研究中，我们评估了长链非编码RNA SOX2OT的表达及其单核苷酸多态性在乳腺癌（BC）发生发展中的作用。
方法
共检测了1106名个体，其中包括505名新诊断的BC患者和601名年龄匹配（±2岁）的对照者。采用实时定量聚合酶链反应检测组织中SOX2OT的表达。使用SNaPshot分析法对rs9839776进行基因分型。
结果
SOX2OT在BC组织中高表达（p < 0.001）。在中国女性中，SOX2OT单核苷酸多态性rs9839776与SOX2OT的高表达及BC风险增加密切相关（优势比：1.42；95%置信区间：1.06 - 1.90；p = 0.018）。
结论
这些结果证实，BC与SOX2OT的高表达显著相关。SOX2OT单核苷酸多态性rs9839776可能通过影响SOX2OT的表达与BC的发病显著相关。
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