Department of Pharmacology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Clinical Trials Center, Chungnam National University Hospital, Daejeon, Republic of Korea.
Medicine (Baltimore). 2023 Oct 27;102(43):e35103. doi: 10.1097/MD.0000000000035103.
Aberrant regulation of the long non-coding RNA SRY-box transcription factor 2 overlapping transcript (SOX2OT) has been reported in various diseases including gastric cancer (GC). However, an association between the well-studied rs9839776 single nucleotide polymorphism in SOX2OT and GC susceptibility has not been reported. This study aimed to evaluate the association between the rs9839776 single nucleotide polymorphism in SOX2OT and GC risk. Genotyping of rs9839776 was conducted using TaqMan genotyping assay for 460 patients with GC and 386 controls. We found that the dominant model (CT+TT) and rs9839776 T allele were significantly associated with decreased GC risk (P = .046, adjusted odds ratio [AOR] = 0.72, 95% confidence interval [CI] = 0.52-1.00 and P = .044, AOR = 0.74, 95% CI = 0.56-0.99, respectively). In addition, stratified analysis revealed that the dominant model (CT+TT) and rs9839776 T allele were significantly associated with decreased risk of lymph node metastasis-negative (P = .039, AOR = 0.67, 95% CI = 0.46-0.98 and P = .049, AOR = 0.71, 95% CI = 0.51-1.00, respectively) and tumor stage I (A+B)/II (A+B+C) (P = .028, AOR = 0.66, 95% CI = 0.50-0.96 and P = .041, AOR = 0.71, 95% CI = 0.52-0.99, respectively) GC. Our findings suggest that the rs9839776 T allele may be a protective factor against GC susceptibility. Further research is needed to clarify whether rs9839776 affects SOX2OT expression.
长链非编码 RNA SOX 盒转录因子 2 重叠转录物（SOX2OT）的异常调节已在包括胃癌（GC）在内的各种疾病中报道。然而，SOX2OT 中研究充分的 rs9839776 单核苷酸多态性与 GC 易感性之间的关联尚未报道。本研究旨在评估 SOX2OT 中 rs9839776 单核苷酸多态性与 GC 风险之间的关联。使用 TaqMan 基因分型检测法对 460 例 GC 患者和 386 例对照进行 rs9839776 基因分型。我们发现，显性模型（CT+TT）和 rs9839776 T 等位基因与 GC 风险降低显著相关（P=0.046，调整后的优势比 [AOR]=0.72，95%置信区间 [CI]=0.52-1.00 和 P=0.044，AOR=0.74，95%CI=0.56-0.99，分别）。此外，分层分析显示，显性模型（CT+TT）和 rs9839776 T 等位基因与淋巴结转移阴性（P=0.039，AOR=0.67，95%CI=0.46-0.98 和 P=0.049，AOR=0.71，95%CI=0.51-1.00，分别）和肿瘤分期 I（A+B）/II（A+B+C）（P=0.028，AOR=0.66，95%CI=0.50-0.96 和 P=0.041，AOR=0.71，95%CI=0.52-0.99，分别）GC 的风险降低显著相关。我们的研究结果表明，rs9839776 T 等位基因可能是 GC 易感性的保护性因素。需要进一步的研究来阐明 rs9839776 是否影响 SOX2OT 的表达。
