Division of Geriatrics, University of São Paulo Medical School, São Paulo, Brazil.
Center for Clinical and Epidemiological Research, Hospital Universitário, University of São Paulo, São Paulo, Brazil.
Int J Geriatr Psychiatry. 2017 Dec;32(12):e188-e194. doi: 10.1002/gps.4698. Epub 2017 Feb 27.
We examined the relationship between coronary artery calcification (CAC) score and performance in cognitive tests in a large Brazilian sample.
In this cross-sectional study, 4104 participants (mean age = 50.9 ± 8.8 years old, 54% female) from the Brazilian Longitudinal Study of Adult Health had complete information for CAC and cognitive tests. We used linear regression models adjusted for sociodemographics, cardiovascular risk factors (hypertension, diabetes, smoking, alcohol use, physical activity, and body mass index), depression, and thyroid function. To investigate potential different associations for middle-aged and older adults, we stratified the analysis by age groups.
Participants with CAC ≥ 100 Agatston score had poorer performance in the trail making test compared to those with CAC < 100 Agatston score (β = -0.101, 95% CI = -0.194; -0.010, p = 0.03). We did not find any other association between CAC and cognitive tests. When we investigated the effect modification between CAC and age on cognitive tests, only the effect modification on global cognition (p = 0.02) and trail making test was significant (p = 0.0003).
Higher CAC was weakly associated with poorer performance in an executive function test in a large sample from the Brazilian Longitudinal Study of Adult Health. Copyright © 2017 John Wiley & Sons, Ltd.
我们在一个大型巴西样本中研究了冠状动脉钙化 (CAC) 评分与认知测试表现之间的关系。
在这项横断面研究中，巴西成人健康纵向研究的 4104 名参与者（平均年龄 50.9 ± 8.8 岁，54%为女性）有完整的 CAC 和认知测试信息。我们使用线性回归模型调整了社会人口统计学、心血管危险因素（高血压、糖尿病、吸烟、饮酒、体力活动和体重指数）、抑郁和甲状腺功能。为了研究中年和老年人潜在的不同关联，我们按年龄组进行了分层分析。
CAC≥100 个 Agatston 评分的参与者在连线测试中的表现差于 CAC＜100 个 Agatston 评分的参与者（β=-0.101，95%CI=-0.194；-0.010，p=0.03）。我们没有发现 CAC 与认知测试之间的其他关联。当我们研究 CAC 和年龄对认知测试的效应修饰作用时，只有对总体认知（p=0.02）和连线测试（p=0.0003）的效应修饰作用有统计学意义。
在巴西成人健康纵向研究的一个大样本中，较高的 CAC 与执行功能测试中的表现较差弱相关。版权所有 © 2017 约翰威立父子公司。
