Munukka Matti, Waller Benjamin, Häkkinen Arja, Nieminen Miika T, Lammentausta Eveliina, Kujala Urho M, Paloneva Juha, Kautiainen Hannu, Kiviranta Ilkka, Heinonen Ari
1Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FINLAND; 2Department of Physical Medicine and Rehabilitation, Central Finland Central Hospital, Jyväskylä, FINLAND; 3Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, FINLAND; 4Department of Diagnostic Radiology, Oulu University Hospital, Oulu, FINLAND; 5Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, FINLAND; 6Department of Surgery, Central Finland Central Hospital, Jyväskylä, FINLAND; 7Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, FINLAND; 8Unit of Primary Health Care, Kuopio University Hospital, Kuopio, FINLAND; and 9Department of Orthopaedics and Traumatology, University of Helsinki, and Helsinki University Hospital, Helsinki, FINLAND.
Med Sci Sports Exerc. 2017 Jul;49(7):1323-1330. doi: 10.1249/MSS.0000000000001238.
To study the relationship between 12-month leisure-time physical activity (LTPA) level and changes in estimated biochemical composition of tibiofemoral cartilage in postmenopausal women with mild knee osteoarthritis (OA).
Originally, 87 volunteer postmenopausal women, age 60 to 68 yr, with mild knee OA (Kellgren Lawrence I/II and knee pain) participated in a randomized controlled, 4-month aquatic training trial (RCT), after which 76 completed the 12-month postintervention follow-up period. Self-reported LTPA was collected along the 12-month period using a diary from which MET task hours per month were calculated. Participants were divided into MET task hour tertiles: 1, lowest (n = 25); 2 = middle (n = 25) and 3 = highest (n = 26). The biochemical composition of the cartilage was estimated using transverse relaxation time (T2) mapping sensitive to the properties of the collagen network and delayed gadolinium-enhanced magnetic resonance imaging of the cartilage (dGEMRIC index) sensitive to the cartilage glycosaminoglycan content. Secondary outcomes were cardiorespiratory fitness, isometric knee extension and flexion force, and the knee injury and OA outcome questionnaire.
During the 12-month follow-up period, there was a significant linear relationship between higher LTPA level and increased dGEMRIC index changes in the posterior region of interest (ROI) of the lateral (P = 0.003 for linearity) and medial (P = 0.006) femoral cartilage. Furthermore, these changes were seen in the posterior lateral femoral cartilage superficial (P = 0.004) and deep (P = 0.007) ROI and in the posterior medial superficial ROI (P < 0.001). There was no linear relationship between LTPA level and other measured variables.
These results suggest that higher LTPA level is related to regional increases in estimated glycosaminoglycan content of tibiofemoral cartilage in postmenopausal women with mild knee OA as measured with dGEMRIC index during a 12-month period.
研究绝经后轻度膝关节骨关节炎（OA）女性12个月休闲时间身体活动（LTPA）水平与胫股关节软骨估计生化成分变化之间的关系。
最初，87名年龄在60至68岁之间、患有轻度膝关节OA（Kellgren Lawrence I/II级且有膝关节疼痛）的绝经后女性志愿者参加了一项为期4个月的随机对照水上训练试验（RCT），之后76人完成了干预后12个月的随访期。在这12个月期间，使用日记收集自我报告的LTPA，并据此计算每月的代谢当量（MET）任务小时数。参与者被分为MET任务小时三分位数：1，最低（n = 25）；2 = 中等（n = 25）；3 = 最高（n = 26）。使用对胶原网络特性敏感的横向弛豫时间（T2）映射和对软骨糖胺聚糖含量敏感的软骨延迟钆增强磁共振成像（dGEMRIC指数）来估计软骨的生化成分。次要结局指标包括心肺适能、等长膝关节伸展和屈曲力量，以及膝关节损伤和OA结局问卷。
在12个月的随访期内，较高的LTPA水平与外侧（线性关系P = 0.003）和内侧（P = 0.006）股骨软骨感兴趣区域（ROI）后部的dGEMRIC指数变化增加之间存在显著的线性关系。此外，这些变化在股骨外侧软骨后部浅表层（P = 0.004）和深层（P = 0.007）ROI以及股骨内侧后部浅表层ROI（P < 0.001）中可见。LTPA水平与其他测量变量之间无线性关系。
这些结果表明，在12个月期间，较高的LTPA水平与绝经后轻度膝关节OA女性胫股关节软骨估计糖胺聚糖含量的区域增加有关，这是通过dGEMRIC指数测量得出的。
