Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Melbourne, Australia.
Osteoarthritis Cartilage. 2016 Oct;24(10):1708-1717. doi: 10.1016/j.joca.2016.05.007. Epub 2016 May 19.
To study the efficacy of aquatic resistance training on biochemical composition of tibiofemoral cartilage in postmenopausal women with mild knee osteoarthritis (OA).
Eighty seven volunteer postmenopausal women, aged 60-68 years, with mild knee OA (Kellgren-Lawrence grades I/II and knee pain) were recruited and randomly assigned to an intervention (n = 43) and control (n = 44) group. The intervention group participated in 48 supervised aquatic resistance training sessions over 16 weeks while the control group maintained usual level of physical activity. The biochemical composition of the medial and lateral tibiofemoral cartilage was estimated using single-slice transverse relaxation time (T2) mapping and delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC index). Secondary outcomes were cardiorespiratory fitness, isometric knee extension and flexion force and knee injury and OA outcome (KOOS) questionnaire.
After 4-months aquatic training, there was a significant decrease in both T2 -1.2 ms (95% confidence interval (CI): -2.3 to -0.1, P = 0.021) and dGEMRIC index -23 ms (-43 to -3, P = 0.016) in the training group compared to controls in the full thickness posterior region of interest (ROI) of the medial femoral cartilage. Cardiorespiratory fitness significantly improved in the intervention group by 9.8% (P = 0.010).
Our results suggest that, in postmenopausal women with mild knee OA, the integrity of the collagen-interstitial water environment (T2) of the tibiofemoral cartilage may be responsive to low shear and compressive forces during aquatic resistance training. More research is required to understand the exact nature of acute responses in dGEMRIC index to this type of loading. Further, aquatic resistance training improves cardiorespiratory fitness.
ISRCTN65346593.
研究水阻力训练对绝经后轻度膝骨关节炎（OA）女性的胫股软骨生化成分的疗效。
招募了 87 名年龄在 60-68 岁之间、有轻度膝 OA（Kellgren-Lawrence 分级 I/II 级和膝痛）的绝经后志愿者，并将其随机分配到干预组（n=43）和对照组（n=44）。干预组参加了 48 次 16 周的监督性水阻力训练，而对照组则保持了正常的身体活动水平。使用单层面横向弛豫时间（T2）图谱和延迟钆增强磁共振成像软骨（dGEMRIC 指数）评估内侧和外侧胫股软骨的生化成分。次要结果是心肺功能适应性、等长膝关节伸肌和屈肌力量以及膝关节损伤和 OA 结局（KOOS）问卷。
经过 4 个月的水疗训练，与对照组相比，训练组内侧股骨软骨全层后 ROI 的 T2 降低了 1.2ms（95%置信区间（CI）：-2.3 至-0.1，P=0.021），dGEMRIC 指数降低了 23ms（-43 至-3，P=0.016）。干预组的心肺功能适应性显著提高了 9.8%（P=0.010）。
我们的研究结果表明，在绝经后轻度膝 OA 女性中，胫股软骨的胶原间质水环境（T2）的完整性可能对水阻力训练中的低切变力和压缩力有反应。需要进一步的研究来了解这种负荷对 dGEMRIC 指数的急性反应的确切性质。此外，水阻力训练可提高心肺功能适应性。
ISRCTN65346593。
