Saba Mohammad Ali, Valeh Toraj, Ehteram Hasan, Haddad Kashani Hamed, Ghazi Zahedi Mahdiyeh
Department of Internal Medicine, Kashan University of Medical Sciences, Kashan, Iran. Email:
Asian Pac J Cancer Prev. 2017 Jan 1;18(1):257-261. doi: 10.22034/APJCP.2017.18.1.257.
Introduction: Pleural effusion diagnosis plays an important role in determining treatment strategies. The aim of this study was to determine the diagnostic capacity of tumor markers CA 15-3 and NSE solely or in combination in differentiating the nature of pleural fluid. Methods and Materials: In this cross-sectional study we evaluated 93 patients with pleural effusions (44 malignant and 49 benign). NSE and CA 15-3 serum and pleural levels were measured simultaneously using immunoenzyme assay kits. Diagnosis was established on the basis of cytological study. Results: Sensitivity and specificity of CA 15-3 serum and pleural level measurement were 70.4%, 49.0%, and 79.5% and 49.0%, respectively. Serum NSE levels had 75.0% sensitivity and 69.4% specificity while the respective pleural figures were 75.0% and 73.5%. The combination of NSE and CA 15-3 serum and pleural levels had the highest sensitivity (93.2%), although combined serum levels had the lowest sensitivity (47.7%). With an accuracy of 74.2%, pleural levels of NSE had the highest diagnostic potential. Conclusion: Measuring NSE and CA 15-3 tumor markers is a suitable approach to distinguish the nature of pleural effusions, with NSE pleural levels demonstrating the highest diagnostic accuracy.
胸腔积液的诊断在确定治疗策略方面起着重要作用。本研究的目的是确定肿瘤标志物CA 15 - 3和神经元特异性烯醇化酶（NSE）单独或联合使用时鉴别胸腔积液性质的诊断能力。方法和材料：在这项横断面研究中，我们评估了93例胸腔积液患者（44例恶性和49例良性）。使用免疫酶分析试剂盒同时检测NSE和CA 15 - 3的血清和胸腔积液水平。诊断基于细胞学研究。结果：CA 15 - 3血清和胸腔积液水平测量的敏感性和特异性分别为70.4%、49.0%以及79.5%、49.0%。血清NSE水平的敏感性为75.0%，特异性为69.4%，而胸腔积液相应的数据分别为75.0%和73.5%。NSE与CA 15 - 3血清和胸腔积液水平联合检测具有最高的敏感性（93.2%），尽管联合血清水平的敏感性最低（47.7%）。NSE胸腔积液水平的诊断潜力最高，准确率为74.2%。结论：检测NSE和CA 15 - 3肿瘤标志物是鉴别胸腔积液性质的合适方法，其中NSE胸腔积液水平的诊断准确性最高。
