Moscat J, Iglesias S, Moreno F, Herrero C, Garcia-Barreno P
Department of Experimental Medicine, Hospital Provincial, Madrid, Spain.
Circ Shock. 1987;23(2):85-92.
Lipopolysaccharide treatment of platelets in basal conditions does not produce any effect on serotonin secretion or on phosphatidic acid synthesis or arachidonic acid release. However, a brief exposure of platelets to endotoxin enhances the thrombin-stimulated activation of these parameters, whereas a more prolonged treatment with lipopolysaccharide impairs thrombin action. The results presented here also suggest that very short-term treatment of platelets with lipopolysaccharide activates the inositol 1,4,5-trisphosphate 3-kinase. The long-term effects of endotoxin could be mediated by protein kinase C activation.
在基础条件下，用脂多糖处理血小板对5-羟色胺分泌、磷脂酸合成或花生四烯酸释放均无任何影响。然而，血小板短暂暴露于内毒素会增强凝血酶刺激的这些参数的激活，而用脂多糖进行更长时间的处理则会损害凝血酶的作用。本文给出的结果还表明，用脂多糖对血小板进行极短期处理会激活肌醇-1,4,5-三磷酸3-激酶。内毒素的长期作用可能由蛋白激酶C激活介导。
