el Deeb M, Roszkowski M, el Deeb M E
Department of Oral and Maxillofacial Surgery, University of Minnesota, Minneapolis.
Cleft Palate J. 1987 Oct;24(4):304-13.
The purpose of this study was to evaluate the use of nonporous hydroxylapatite (HA) granules as an extracranial and extranasal augmentation material in dogs. Clinical evaluation revealed that the HA granules became stable within 6 weeks and lost some of the augmented height. Histologic evaluation revealed no evidence of inflammation, bone resorption, or bone formation; also the granules were separated from other granules and the cranial surface by a layer of collagen fibers. This study concluded that nonporous HA granules are a practical extracranial and extranasal augmentation material, but its final augmentation contour is difficult to predict and control because of the consistency of the material. Either researchers need to develop a better method to stabilize HA granules in extracranial and extranasal applications or they need access to an HA block material that maintains better augmented contour.
本研究的目的是评估无孔羟基磷灰石（HA）颗粒作为犬颅外和鼻外填充材料的应用。临床评估显示，HA颗粒在6周内变得稳定，但填充高度有所降低。组织学评估显示没有炎症、骨吸收或骨形成的迹象；颗粒之间以及颗粒与颅骨表面之间被一层胶原纤维分隔。本研究得出结论，无孔HA颗粒是一种实用的颅外和鼻外填充材料，但由于材料的稠度，其最终填充轮廓难以预测和控制。研究人员要么需要开发一种更好的方法来在颅外和鼻外应用中稳定HA颗粒，要么需要获得一种能保持更好填充轮廓的HA块状材料。
