小鼠LMTK细胞金属硫蛋白-I基因的克隆与特性分析
Cloning and characterization of the metallothionein-I gene from mouse LMTK cells.
作者信息
Brzezinski R, Smorawinska M, Vézina G, Thibodeau J, Thirion J P
机构信息
Département de Microbiologie, Faculté de Médecine, Université de Sherbrooke, Québec, Canada.
出版信息
Cytobios. 1987;52(208):33-8.
PMID:2824133
Abstract
A clone of about 14 kb containing the metallothionein MT-I gene and three repetitive sequences, was isolated from a genomic library of mouse LMTK DNA. The MT-I gene was functional. Transfected cells became cadmium resistant. Two of the three repetitive sequences were moderately repetitive while the other was closely related to the R family.
摘要
从小鼠LMTK DNA的基因组文库中分离出一个约14 kb的克隆，其中包含金属硫蛋白MT-I基因和三个重复序列。MT-I基因具有功能。转染的细胞对镉具有抗性。三个重复序列中的两个是中度重复的，而另一个与R家族密切相关。
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