Cao Shun, Wang Taisheng, Sun Qiang, Hu Bingliang, Yu Weixing
Opt Express. 2017 Feb 20;25(4):3863-3874. doi: 10.1364/OE.25.003863.
Biological research requires dynamic and wide-field optical microscopy with resolution down to nanometer to study the biological process in a sub-cell or single molecular level. To address this issue, we propose a dynamic wide-field optical nanoimaging method based on a meta-nanocavity platform (MNCP) model which can be incorporated in micro/nano-fluidic systems so that the samples to be observed can be confined in a nano-scale space for the ease of imaging. It is found that this platform can support standing wave surface plasmons (SW-SPs) interference pattern with a period of 105 nm for a 532 nm incident wavelength. Furthermore, the potential application of the NCP for wide-field super-resolution imaging was discussed and the simulation results show that an imaging resolution of sub-80 nm can be achieved.
生物学研究需要具有纳米级分辨率的动态宽场光学显微镜，以便在亚细胞或单分子水平上研究生物过程。为了解决这个问题，我们提出了一种基于超纳米腔平台（MNCP）模型的动态宽场光学纳米成像方法，该模型可集成到微纳流体系统中，从而将待观察的样品限制在纳米级空间内，便于成像。研究发现，对于532nm的入射波长，该平台可以支持周期为105nm的驻波表面等离子体激元（SW-SPs）干涉图案。此外，还讨论了该超纳米腔在宽场超分辨率成像方面的潜在应用，模拟结果表明可以实现低于80nm的成像分辨率。
