Davis Adam, Amin Nirav M, Johnson Caroline, Bagley Kristen, Ghashghaei H Troy, Nascone-Yoder Nanette
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA
Development. 2017 Apr 15;144(8):1477-1483. doi: 10.1242/dev.143701. Epub 2017 Feb 27.
Left-right (LR) asymmetry is a fundamental feature of internal anatomy, yet the emergence of morphological asymmetry remains one of the least understood phases of organogenesis. Asymmetric rotation of the intestine is directed by forces outside the gut, but the morphogenetic events that generate anatomical asymmetry in other regions of the digestive tract remain unknown. Here, we show in mouse and that the mechanisms that drive the curvature of the stomach are intrinsic to the gut tube itself. The left wall of the primitive stomach expands more than the right wall, as the left epithelium becomes more polarized and undergoes radial rearrangement. These asymmetries exist across several species, and are dependent on LR patterning genes, including , and Our findings have implications for how LR patterning manifests distinct types of morphological asymmetries in different contexts.
左右（LR）不对称是内部解剖结构的一个基本特征，然而形态不对称的出现仍然是器官发生过程中最不为人所理解的阶段之一。肠道的不对称旋转是由肠道外部的力量引导的，但在消化道其他区域产生解剖学不对称的形态发生事件仍然未知。在这里，我们在小鼠中发现，驱动胃弯曲的机制是肠管本身所固有的。原始胃的左壁比右壁扩张得更多，因为左上皮细胞变得更加极化并经历径向重排。这些不对称现象存在于多个物种中，并依赖于LR模式基因，包括 、 和 。我们的发现对于LR模式在不同背景下如何表现出不同类型的形态不对称具有启示意义。
