系统性红斑狼疮中的塌陷性肾小球病
Collapsing glomerulopathy in systemic lupus erythematosus.
作者信息
Abadeer Kerolos, Alsaad Ali A, Geiger Xochiquetzal J, Porter Ivan E
机构信息
Department of Nephrology and Hypertension, Mayo Clinic Florida, Jacksonville, Florida, USA.
Department of Internal Medicine, Mayo Clinic Florida, Jacksonville, Florida, USA.
出版信息
BMJ Case Rep. 2017 Feb 27;2017:bcr2016217840. doi: 10.1136/bcr-2016-217840.
Abstract
Collapsing glomerulopathy (CG) is a rare disease that can be associated with multiple other disorders. It usually leads to poor prognosis with a high percentage of patients progressing to end-stage renal disease. In this article, we illustrate a clinical case of CG associated with systemic lupus erythematosus that had a prompt response to mycophenolate and prednisone. The condition started after sudden cessation of the already established mycophenolate treatment regimen. The patient then presented with acute kidney injury due to kidney biopsy-proven CG. In that circumstance, we hypothesised that mycophenolate may play a role in prevention and development of CG.
摘要
塌陷性肾小球病（CG）是一种罕见疾病，可与多种其他病症相关。它通常导致预后不良，有很高比例的患者进展至终末期肾病。在本文中，我们阐述了一例与系统性红斑狼疮相关的CG临床病例，该病例对霉酚酸酯和泼尼松迅速产生反应。病情在已确立的霉酚酸酯治疗方案突然停止后出现。该患者随后因肾活检证实的CG出现急性肾损伤。在这种情况下，我们推测霉酚酸酯可能在CG的预防和发展中起作用。
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