Muniz Monique Pereira Rêgo, Brito Laise Pereira Arcoverde Fechine, Vale Pedro Henrique Cavalcante, Guedes Felipe Leite, Oliveira Thina Klicia Mendonça, de Araújo Brito Dyego José, Filho Natalino Salgado, Dantas Márcio, Silva Gyl Eanes Barros
Department of Nephrology, Presidente Dutra Universitary Hospital, University of Maranhão (UFMA), São Luís, MA, Brazil.
Department of Nephrology, Onofre Lopes Universitary Hospital, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Arch Med Sci. 2020 Jun 23;19(5):1398-1409. doi: 10.5114/aoms.2020.96617. eCollection 2023.
A common criticism of the classification of lupus nephritis is the relative scarcity of information regarding tubular, interstitial, and vascular changes compared to the available information regarding glomerular changes, even though their potential for independent progression is known. This study reviewed the importance of less explored lesions by the current and widely used 2003 classification of lupus nephritis of the International Society of Nephrology/Renal Pathology Society (ISN/RPS), with emphasis on the tubulointerstitial, podocyte, and vascular lesions, increasingly recognised as being important in the pathogenesis and prognosis of the disease. Recognition of these lesions can help with therapeutic decision-making, thereby allowing better results for patients with systemic lupus erythematosus.
对狼疮性肾炎分类的一个常见批评是，与现有关于肾小球变化的信息相比，关于肾小管、间质和血管变化的信息相对较少，尽管它们独立进展的可能性是已知的。本研究回顾了国际肾脏病学会/肾脏病理学会（ISN/RPS）目前广泛使用的2003年狼疮性肾炎分类中较少探索的病变的重要性，重点关注肾小管间质、足细胞和血管病变，这些病变在该疾病的发病机制和预后中日益被认为是重要的。认识到这些病变有助于治疗决策，从而为系统性红斑狼疮患者带来更好的治疗效果。
